Screening for colorectal cancer: possible improvements by risk assessment evaluation?
Screening for colorectal cancer: possible improvements by risk assessment evaluation?
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DOI：
10.3109/00365521.2011.610002
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发表时间：
2011-11
影响因子：
1.9
通讯作者：
Danish Study Group on Early Detection of Colorectal Cancer
中科院分区：
文献类型：
--
作者：
Nielsen HJ;Jakobsen KV;Christensen IJ;Brünner N;Danish Study Group on Early Detection of Colorectal Cancer
新的研究结果表明，筛查可提高结直肠癌患者的生存率。因此，在亚洲、欧洲和北美已经实施或正在考虑实施筛查方案。目前，筛查方法种类繁多，包括结肠镜和乙状结肠镜检查、CT和MR结肠造影、胶囊内镜检查、DNA和粪便潜血检查等。各种检查的利弊，包括经济问题，都存在争议。尽管有大量经过评估和验证的检测方法，甚至具有高特异性和合理的敏感性，但尚未就筛查程序达成国际共识。在目前的筛选程序中，遵守情况相当有限，这是一个重大的缺点。此外，有些程序费用很高，因此需要这些程序的选择方法。目前对改善结直肠癌筛查的研究包括基于血液的生物标志物，如蛋白质，DNA和RNA，结合各种人口统计学和临床参数进行“风险评估评估”（RAE）测试。据推测，这样的测试可能会导致更高的接受筛查人群，从而提高依从性。此外，包括社交媒体在内的媒体的参与可能会使更多的人加入筛查计划。实施经验证的RAE和逐步改进的筛查方法可能会改革结直肠癌筛查程序的成本/效益。因此，目前的研究结果，验证RAE测试，期待与兴趣。
Emerging results indicate that screening improves survival of patients with colorectal cancer. Therefore, screening programs are already implemented or are being considered for implementation in Asia, Europe and North America. At present, a great variety of screening methods are available including colono- and sigmoidoscopy, CT- and MR-colonography, capsule endoscopy, DNA and occult blood in feces, and so on. The pros and cons of the various tests, including economic issues, are debated. Although a plethora of evaluated and validated tests even with high specificities and reasonable sensitivities are available, an international consensus on screening procedures is still not established. The rather limited compliance in present screening procedures is a significant drawback. Furthermore, some of the procedures are costly and, therefore, selection methods for these procedures are needed. Current research into improvements of screening for colorectal cancer includes blood-based biological markers, such as proteins, DNA and RNA in combination with various demographically and clinically parameters into a “risk assessment evaluation” (RAE) test. It is assumed that such a test may lead to higher acceptance among the screening populations, and thereby improve the compliances. Furthermore, the involvement of the media, including social media, may add even more individuals to the screening programs. Implementation of validated RAE and progressively improved screening methods may reform the cost/benefit of screening procedures for colorectal cancer. Therefore, results of present research, validating RAE tests, are awaited with interest.
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影响因子：
39.2
作者：
Ahlquist DA;Sargent DJ;Loprinzi CL;Levin TR;Rex DK;Ahnen DJ;Knigge K;Lance MP;Burgart LJ;Hamilton SR;Allison JE;Lawson MJ;Devens ME;Harrington JJ;Hillman SL
通讯作者：
Hillman SL
影响因子：
2.2
作者：
Foley, J.;O'Neill, M.
通讯作者：
O'Neill, M.
影响因子：
39.2
作者：
Brenner, Hermann;Chang-Claude, Jenny;Hoffmeister, Michael
通讯作者：
Hoffmeister, Michael
影响因子：
9.3
作者：
deVos, Theo;Tetzner, Reimo;Lofton-Day, Catherine
通讯作者：
Lofton-Day, Catherine
影响因子：
1.9
作者：
Brasso, Klaus;Ladelund, Steen;Jorgensen, Torben
通讯作者：
Jorgensen, Torben