Deformation of the Lamina Cribrosa and Optic Nerve Due to Changes in Cerebrospinal Fluid Pressure.
Deformation of the Lamina Cribrosa and Optic Nerve Due to Changes in Cerebrospinal Fluid Pressure.
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DOI：
10.1167/iovs.16-21393
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发表时间：
2017-04-01
影响因子：
4.4
通讯作者：
Ethier CR
中科院分区：
文献类型：
--
作者：
Feola AJ;Coudrillier B;Mulvihill J;Geraldes DM;Vo NT;Albon J;Abel RL;Samuels BC;Ethier CR
脑脊液压力（CSFp）的变化涉及或牵涉到各种眼部疾病，包括青光眼，特发性颅内高压，视力损害和颅内压综合征。然而，鲜为人知的是，对筛板和后板神经组织（RLNT）的生物力学，在这些条件下可能是重要的CSF β的影响。我们的目标是使用一种实验方法来可视化和量化这些组织的变形CSFp增加。在眼内压为15 mm Hg和CSFps为4、10、20和30 mm Hg的条件下，使用同步辐射相位衬度显微计算机断层扫描（PC μCT）对猪眼（n = 3）的后眼和RLNT进行成像。在每个CSFp步骤采集每个组织区域的扫描，并使用数字体积相关性进行分析，以确定三维组织变形。升高CSF p增加了所有三个标本的筛板和RLNT中的应变，其中最大的应变发生在RLNT中。相对于4 mm Hg的基线CSF p，在30 mm Hg下，筛板经历的平均第一和第三主应变分别为4.4%和− 3.5%。RLNT的相应值为9.5%和-9.1%。CSFp对筛板内的应变分布有显著影响，更突出的是，对RLNT内的应变分布有显著影响。CSFp的升高与每个区域的变形增加呈正相关，并且可能在与CSFp变化相关的眼部病理中起作用。
Cerebrospinal fluid pressure (CSFp) changes are involved or implicated in various ocular conditions including glaucoma, idiopathic intracranial hypertension, and visual impairment and intracranial pressure syndrome. However, little is known about the effects of CSFp on lamina cribrosa and retrolaminar neural tissue (RLNT) biomechanics, potentially important in these conditions. Our goal was to use an experimental approach to visualize and quantify the deformation of these tissues as CSFp increased. The posterior eye and RLNT of porcine eyes (n = 3) were imaged using synchrotron radiation phase-contrast micro-computed tomography (PC μCT) at an intraocular pressure of 15 mm Hg and CSFps of 4, 10, 20, and 30 mm Hg. Scans of each tissue region were acquired at each CSFp step and analyzed using digital volume correlation to determine 3-dimensional tissue deformations. Elevating CSFp increased the strain in the lamina cribrosa and RLNT of all three specimens, with the largest strains occurring in the RLNT. Relative to the baseline CSFp of 4 mm Hg, at 30 mm Hg, the lamina cribrosa experienced a mean first and third principal strain of 4.4% and −3.5%, respectively. The corresponding values for the RLNT were 9.5% and −9.1%. CSFp has a significant impact on the strain distributions within the lamina cribrosa and, more prominently, within the RLNT. Elevations in CSFp were positively correlated with increasing deformations in each region and may play a role in ocular pathologies linked to changes in CSFp.
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影响因子：
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