Mussel-inspired silver-releasing antibacterial hydrogels.
Mussel-inspired silver-releasing antibacterial hydrogels.
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DOI：
10.1016/j.biomaterials.2012.02.027
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发表时间：
2012-05
期刊：
影响因子：
14
通讯作者：
Messersmith, Phillip B.
中科院分区：
文献类型：
--
作者：
Fullenkamp, Dominic E.;Rivera, Jose G.;Gong, Yong-kuan;Lau, K. H. Aaron;He, Lihong;Varshney, Rahul;Messersmith, Phillip B.
开发了同时允许银纳米颗粒形成和凝胶固化的银释放抗菌水凝胶。受贻贝粘附蛋白的启发，合成了含有反应性儿茶酚部分的水溶性聚乙二醇（PEG）聚合物，其中含有氨基酸3，4-二羟基苯丙氨酸（DOPA）的儿茶酚在贻贝粘附到水性环境中的几乎任何表面的能力中起重要作用。我们利用银氧化聚合物儿茶酚，导致共价交联和水凝胶形成，同时还原Ag（I）。银释放在PBS溶液中持续至少两周的时间。发现水凝胶抑制细菌生长，与众所周知的银的抗菌特性一致，同时不显著影响哺乳动物细胞活力。此外，发现薄的水凝胶膜抵抗细菌和哺乳动物细胞附着，与PEG的疏水特性一致。我们相信这些材料具有很强的潜力，抗菌生物材料涂层和组织粘合剂，由于儿茶酚的材料独立的粘合性能。
A silver-releasing antibacterial hydrogel was developed that simultaneously allowed for silver nanoparticle formation and gel curing. Water-soluble polyethylene glycol (PEG) polymers were synthesized that contain reactive catechol moieties, inspired by mussel adhesive proteins, where the catechol containing amino acid 3,4-dihydroxyphenylalanine (DOPA) plays an important role in the ability of the mussel to adhere to almost any surface in an aqueous environment. We utilized silver nitrate to oxidize polymer catechols, leading to covalent cross-linking and hydrogel formation with simultaneous reduction of Ag(I). Silver release was sustained for periods of at least two weeks in PBS solution. Hydrogels were found to inhibit bacterial growth, consistent with the well-known antibacterial properties of silver, while not significantly affecting mammalian cell viability. In addition, thin hydrogel films were found to resist bacterial and mammalian cell attachment, consistent with the antifouling properties of PEG. We believe these materials have a strong potential for antibacterial biomaterial coatings and tissue adhesives, due to the material-independent adhesive properties of catechols.
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影响因子：
14
作者：
Brubaker, Carrie E.;Kissler, Hermann;Wang, Ling-Jia;Kaufman, Dixon B.;Messersmith, Phillip B.
通讯作者：
Messersmith, Phillip B.
影响因子：
6.2
作者：
Travan, Andrea;Pelillo, Chiara;Paoletti, Sergio
通讯作者：
Paoletti, Sergio
影响因子：
5.5
作者：
Westwood, Glenn;Horton, Trinity N.;Wilker, Jonathan J.
通讯作者：
Wilker, Jonathan J.
影响因子：
3.1
作者：
Leaper, David J
通讯作者：
Leaper, David J
影响因子：
120.7
作者：
Goldmann, DA;Weinstein, RA;Martone, WJ
通讯作者：
Martone, WJ