Helicobacter pylori update: gastric cancer, reliable therapy, and possible benefits.
Helicobacter pylori update: gastric cancer, reliable therapy, and possible benefits.
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DOI：
10.1053/j.gastro.2015.01.040
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发表时间：
2015-04
期刊：
影响因子：
29.4
通讯作者：
Graham DY
中科院分区：
文献类型：
--
作者：
Graham DY
幽门螺杆菌感染有助于多种胃和胃外疾病的发展。感染是胃腺癌发生的必要条件，但不是充分条件。它的根除将消除世界范围内癌症死亡的主要原因，因此人们对确定如何，如果以及何时可以实现这一目标非常感兴趣。幽门螺杆菌与胃癌的发生发展有多种机制。胃腺癌是许多与炎症相关的癌症之一，其由幽门螺杆菌感染引起，然而细菌也引起遗传和表观遗传变化，导致胃上皮细胞的遗传不稳定。幽门螺杆菌根除可减少这两种情况。然而，在确定治疗这种细菌感染是否会预防癌症或仅降低其风险时，必须考虑许多因素，这些因素必须在设计可靠有效的根除疗法时加以考虑。此外，幽门螺杆菌感染已被提出提供一些益处，例如降低肥胖或儿童哮喘的风险，尽管没有令人信服的数据支持幽门螺杆菌感染的益处。
Helicobacter pylori infection contributes to development of diverse gastric and extra-gastric diseases. The infection is necessary but not sufficient for development of gastric adenocarcinoma. Its eradication would eliminate a major worldwide cause of cancer death, so there is much interest in identifying how, if, and when this can be accomplished. There are several mechanisms by which H pylori contributes to development of gastric cancer. Gastric adenocarcinoma is one of many cancers associated with inflammation, which is induced by H pylori infection, yet the bacteria also cause genetic and epigenetic changes that lead to genetic instability in gastric epithelial cells. H pylori eradication reduces both. However, many factors must be considered in determining whether treating this bacterial infection will prevent cancer or only reduce its risk—these must be considered in designing reliable and effective eradication therapies. Furthermore, H pylori infection has been proposed to provide some benefits, such as reducing the risks of obesity or childhood asthma, although there are no convincing data to support the benefits of H pylori infections.
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DOI：
10.1086/590158
发表时间：
2008-08-15
期刊：
The Journal of infectious diseases
影响因子：
--
作者：
Chen Y;Blaser MJ
通讯作者：
Blaser MJ
DOI：
10.1073/pnas.1310750111
发表时间：
2014-01-14
影响因子：
11.1
作者：
Fujimura, Kei E.;Demoor, Tine;Lynch, Susan V.
通讯作者：
Lynch, Susan V.
影响因子：
11.8
作者：
Calvet, Xavier;Sanchez-Delgado, Jordi;Segura, Ferran
通讯作者：
Segura, Ferran
影响因子：
4.4
作者：
Areia, Miguel;Dinis-Ribeiro, Mario;Goncalves, Francisco Rocha
通讯作者：
Goncalves, Francisco Rocha
影响因子：
4.3
作者：
Chang, Wen-Jun;Du, Yan;Cao, Guang-Wen
通讯作者：
Cao, Guang-Wen