Helicobacter pylori colonization is inversely associated with childhood asthma.
Helicobacter pylori colonization is inversely associated with childhood asthma.
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DOI：
10.1086/590158
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发表时间：
2008-08-15
期刊：
影响因子：
--
通讯作者：
Blaser MJ
中科院分区：
文献类型：
--
作者：
Chen Y;Blaser MJ
哮喘是一个严重的全球性健康问题，正在变得越来越普遍。幽门螺杆菌是一种存在于生命早期的主要人类本土微生物，其定植可能与儿童哮喘风险有关。我们使用1999-2000年国家健康与营养调查（NHANES）中7，412名参与者的数据进行了横断面分析，以评估H.幽门螺杆菌和儿童哮喘。H.幽门螺杆菌血清阳性与早发性哮喘（发病年龄< 5岁）和3-13岁儿童的当前哮喘呈负相关。在3-19岁的受试者中，H. pylori与曾患哮喘呈负相关（OR = 0.69; 95% CI = 0.45-1.06），与儿童期（<5岁）哮喘的负相关性更强（OR = 0.58; 95% CI = 0.38-0.88）。在3-13岁的受试者中，H. pylori感染与哮喘的现状呈显著负相关（OR = 0.41，95%CI = 0.24-0.69）。H.幽门螺杆菌也与最近有喘息、过敏性鼻炎、皮炎、湿疹或皮疹呈负相关。这项研究是第一个报告的逆关联的H。幽门螺杆菌与儿童哮喘这些发现为哮喘研究和预防指明了新的方向。
Asthma, a serious health problem worldwide, is growing more common. The colonization of Helicobacter pylori, a major human indigenous (commensal) microbe that is present early in life may be relevant to childhood asthma risk. We conducted cross-sectional analyses using data from 7,412 participants in the National Health and Nutrition Survey (NHANES) 1999–2000 to assess the association between H. pylori and childhood asthma. H. pylori seropositivity was inversely associated with early-onset asthma (onset age < 5 years) and current asthma in children 3–13 years. Among participants 3–19 years of age, the presence of H. pylori was inversely related to ever having asthma (OR = 0.69; 95% CI = 0.45–1.06), and the inverse association with early childhood-onset (<age 5) asthma was stronger (OR = 0.58; 95% CI = 0.38–0.88). Among participants 3–13 years of age, H. pylori was significantly inversely associated with current status of asthma (OR = 0.41; 95% CI = 0.24–0.69). H. pylori also was inversely related to having recently had wheezing, allergic rhinitis, and dermatitis, eczema, or rash. This study is the first to report an inverse association of H. pylori with asthma in children. The findings indicate new directions for research and asthma prevention.
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影响因子：
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