Unilateral nephrectomy in the rat: effects on mercury handling and renal cortical subcellular distribution.
Unilateral nephrectomy in the rat: effects on mercury handling and renal cortical subcellular distribution.
复制标题
大鼠单侧肾切除术：对汞处理和肾皮质亚细胞分布的影响。
DOI：
10.1016/0041-008x(88)90119-6
复制
发表时间：
1988
影响因子：
3.8
通讯作者：
W. Berndt
中科院分区：
文献类型：
--
作者：
M. Houser;W. Berndt
由于单侧肾切除术（UNX）与增强的氯化汞肾毒性有关，因此进行了研究以表征UNX对大鼠组织含量、尿排泄和肾皮质亚细胞汞分布的影响。在代偿性肾肥大的不同阶段，立即、UNX后2天或14天对动物进行研究。与假手术对照组相比，所有UNX组在注射后24小时肾皮质中的汞含量较高，在注射后1或3小时立即和2天组中的汞含量较高。然而，UNX与外髓质或内髓质、肝脏、血浆或红细胞中汞含量的任何改变无关。亚细胞分布研究表明，在注射后1、3和24小时，所有UNX组的细胞溶质汞均匀升高，而与“金属硫蛋白样”蛋白结合或游离在细胞溶质中的汞仅在1或3小时增加。或微粒体汞含量在注射UNX后3或24小时立即或14天研究的动物中升高，而在UNX后2天研究的动物在1、3和24小时表现出几乎一致的增加。在所有UNX组中，单肾尿汞排泄量升高，而仅在手术后立即或2天研究的动物中每克肾重的排泄量增加。这些研究表明，代偿性肾肥大的所有阶段都与细胞质和关键细胞器中汞含量的增加有关，这可以解释UNX后肾毒性的增强。
As unilateral nephrectomy (UNX) is associated with enhanced mercuric chloride nephrotoxicity, studies were undertaken to characterize the effects of UNX on the tissue content, urinary excretion, and renal cortical subcellular distribution of mercury in the rat. Animals were studied immediately, 2 days or 14 days following UNX, during separate phases of compensatory renal hypertrophy. As compared to sham surgery controls, mercury content in renal cortex was higher in all UNX groups at 24 hr following injection and in the immediate and 2-day groups at 1 or 3 hr. However, UNX was not associated with any alteration in mercury content within outer or inner medulla, liver, plasma, or red blood cells. Subcellular distribution studies demonstrated that cytosolic mercury was uniformly elevated in all UNX groups at 1, 3, and 24 hr following injection while mercury bound to “metallothionein-like” proteins or free in the cytosol was increased only at 1 or 3 hr. Nuclear, mitochondrial, or microsomal mercury content was elevated in the animals studied immediately or 14 days after UNX at 3 or 24 hr following injection, while animals studied 2 days after UNX demonstrated a nearly uniform increase at 1, 3, and 24 hr. Single-kidney urinary mercyry excretion was elevated in all UNX groups while excretion per gram kidney weight was increased only in the animals studied immediately or 2 days after surgery. These studies suggest that all phases of compensatory renal hypertrophy are associated with an enhanced content of mercury within the cell cytoplasm and in critical cellular organelles, which may explain the enhanced nephrotoxicity seen following UNX.
单侧肾切除术后肾外髓质注射无机汞的积累增加。
影响因子：
3.8
作者：
Zalups,RK;Klotzbach,JM;Diamond,GL
通讯作者：
Diamond,GL
肾皮质巯基在汞引起的肾毒性发展中的作用。
DOI：
10.1080/15287398209530147
发表时间：
1982
期刊：
Journal of toxicology and environmental health
影响因子：
--
作者：
Johnson,DR
通讯作者：
Johnson,DR
大鼠肾脏对膳食蛋白质减少的生理和形态反应。
DOI：
10.1152/ajprenal.1985.248.1.f31
发表时间：
1985
期刊：
The American journal of physiology
影响因子：
--
作者：
Schmidt-Nielsen,B;Barrett,JM;Graves,B;Crossley,B
通讯作者：
Crossley,B