Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers.
Total Blood Mercury Predicts Methylmercury Exposure in Fish and Shellfish Consumers.
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DOI：
10.1007/s12011-021-02968-9
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发表时间：
2022-08
影响因子：
3.9
通讯作者：
Segal, Deborah
中科院分区：
文献类型：
--
作者：
Wells, Ellen M.;Kopylev, Leonid;Nachman, Rebecca;Radke, Elizabeth G.;Congleton, Johanna;Segal, Deborah
许多评估甲基汞(MeHg)毒性的研究依赖于全血总汞(THG)测量来评估MeHg暴露。然而，全血三汞包括其他形式的汞(汞)，如无机汞，其接触来源和毒理作用与甲基汞不同。因此，估算全血甲基汞/三氢汞比率对于预测甲基汞暴露以及随后努力建立暴露-反应关系以用于风险评估至关重要。使用了一个具有代表性的大型数据集(2011年至2016年全国健康和营养检查调查)，以确定(A)自报的鱼类和贝类消费者， ≥ 15岁(“完全成年”人群(N = 5268训练数据集；N = 2336测试数据集))和(B)15-44岁女性鱼类和贝类消费者(“育龄妇女”人群(N = 1285培训数据集；N = 560测试数据集))中的全血甲基汞/三氢汞比率。对THG和MHG的直接测量的未调整和调整的线性和样条模型进行了评估。全血MeHg/THG比值平均值为0.75(95%可信区间分别为0.74、0.75)。在THG浓度较高的人群中，这一比例明显更高。所有模型都表现出很好的适合性(将R2从0.957调整到0.982)。与线性模型相比，样条线模型的性能略有提高。对于成年人口和育龄妇女，未调整的样条线模型预测，当THG浓度为5.80µg/L时，全血甲基汞浓度分别为5.65g/L和5.55g/L。这些结果表明，全血THG可以很好地预测鱼类和贝类消费者的全血甲基汞浓度。网上版载有补充材料，可在10.1007/s12011-021-021-9查阅。
Many studies evaluating methylmercury (MeHg) toxicity rely on whole blood total mercury (THg) measurements to estimate MeHg exposure. However, whole blood THg includes other forms of mercury (Hg), such as inorganic Hg, which have different exposure sources and toxicological effects than MeHg. Therefore, estimating the whole blood MeHg/THg ratio is critical to predicting MeHg exposure and, subsequently, efforts to establish an exposure–response relationship for use in risk assessment. A large, representative dataset (National Health and Nutrition Examination Survey (NHANES) 2011–2016) was used to determine the whole blood MeHg/THg ratio among (a) self-reported fish and shellfish consumers, ≥ 15 years of age (the “full adult” population (N = 5268 training dataset; N = 2336 test dataset)) and (b) female fish and shellfish consumers, 15–44 years of age (the “women of reproductive age” population (N = 1285 training dataset; N = 560 test dataset)). Unadjusted and adjusted linear and spline models with direct measurements for both THg and MeHg were evaluated. The mean whole blood MeHg/THg ratio was 0.75 (95% confidence interval (CI): 0.74, 0.75). This ratio was significantly higher among those with higher THg concentrations. All models exhibited excellent fit (adjusted R2 from 0.957 to 0.982). Performance was slightly improved in spline versus linear models. For the full adult population and women of reproductive age, the unadjusted spline model predicted whole blood MeHg concentrations of 5.65 µg/L and 5.55 µg/L, respectively, when the THg concentration was 5.80 µg/L. These results suggest that whole blood THg is a good predictor of whole blood MeHg among fish and shellfish consumers. The online version contains supplementary material available at 10.1007/s12011-021-02968-9.
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影响因子：
10.4
作者：
Gibb H;O'Leary KG
通讯作者：
O'Leary KG
DOI：
10.1080/00039896.1990.10118754
发表时间：
1990-11-01
期刊：
ARCHIVES OF ENVIRONMENTAL HEALTH
影响因子：
--
作者：
HANSEN, JC;TARP, U;BOHM, J
通讯作者：
BOHM, J
DOI：
10.1186/1476-069x-4-20
发表时间：
2005-10-03
期刊：
Environmental health : a global access science source
影响因子：
--
作者：
Berglund M;Lind B;Björnberg KA;Palm B;Einarsson O;Vahter M
通讯作者：
Vahter M
DOI：
10.1016/j.ijheh.2018.07.011
发表时间：
2019-01-01
影响因子：
6
作者：
Barbone, Fabio;Rosolen, Valentina;Horvat, Milena
通讯作者：
Horvat, Milena
影响因子：
1.7
作者：
Jung, Seon A.;Chung, Dayoung;Pyo, Heesoo
通讯作者：
Pyo, Heesoo