Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans.
Different roles of mast cells in obesity and diabetes: lessons from experimental animals and humans.
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DOI：
10.3389/fimmu.2012.00007
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发表时间：
2012
影响因子：
7.3
通讯作者：
Shi GP
中科院分区：
文献类型：
--
作者：
Shi MA;Shi GP
肥大细胞（MCs）在过敏性高反应和防御微生物感染中起重要作用。最近对实验动物和人类的研究表明，MCs参与肥胖和糖尿病。MC在脂肪组织中的分布和活动可能会有所不同，这取决于不同脂肪组织的位置。除了释放炎症介质影响脂肪组织细胞外基质重塑和促进炎症细胞募集和增殖外，MCs还直接和间接地相互作用并激活脂肪组织细胞，包括脂肪细胞和募集的炎症细胞。肥胖患者血浆MC蛋白酶水平明显高于瘦人。实验性肥胖动物在MC失活后体重减轻。糖尿病中的MC功能更为复杂，取决于糖尿病的类型和不同的糖尿病并发症。血浆MC蛋白酶和MC活化必需免疫球蛋白E水平是人糖尿病前期和糖尿病的重要危险因素。在实验动物中，MC稳定可预防饮食诱导的糖尿病并改善预先建立的糖尿病。至少在实验动物中，MC的消耗或失活可以改善饮食诱导的2型糖尿病和某些形式的1型糖尿病，但也可以使其他形式的1型糖尿病恶化。动物和人类研究的观察结果表明，使用MC稳定剂治疗糖尿病患者有益。一些糖尿病患者可能受益于提高糖尿病细胞的生存和增殖，这些假设值得详细的基础研究和临床研究。
Mast cells (MCs) play an important role in allergic hyperresponsiveness and in defending microorganism infections. Recent studies of experimental animals and humans have suggested that MCs participate in obesity and diabetes. MC distribution and activities in adipose tissues may vary, depending on the locations of different adipose tissues. In addition to releasing inflammatory mediators to affect adipose tissue extracellular matrix remodeling and to promote inflammatory cell recruitment and proliferation, MCs directly and indirectly interact and activate adipose tissue cells, including adipocytes and recruited inflammatory cells. Plasma MC protease levels are significantly higher in obese patients than in lean subjects. Experimental obese animals lose body weight after MC inactivation. MC functions in diabetes are even more complicated, and depend on the type of diabetes and on different diabetic complications. Both plasma MC proteases and MC activation essential immunoglobulin E levels are significant risk factors for human pre-diabetes and diabetes mellitus. MC stabilization prevents diet-induced diabetes and improves pre-established diabetes in experimental animals. MC depletion or inactivation can improve diet-induced type 2 diabetes and some forms of type 1 diabetes, but also can worsen other forms of type 1 diabetes, at least in experimental animals. Observations from animal and human studies have suggested beneficial effects of treating diabetic patients with MC stabilizers. Some diabetic patients may benefit from enhancing MC survival and proliferation – hypotheses that merit detailed basic researches and clinical studies.
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DOI：
10.1590/s0074-02762005000900021
发表时间：
2005-03-01
期刊：
Memórias do Instituto Oswaldo Cruz
影响因子：
--
作者：
Carvalho, Vinicius F;Barreto, Emiliano O;e Silva, Patrícia MR
通讯作者：
e Silva, Patrícia MR
DOI：
10.1111/j.1365-2125.1980.tb01791.x
发表时间：
1980-01-01
影响因子：
3.4
作者：
CLARKE, CW;MAY, CS
通讯作者：
MAY, CS
影响因子：
15.9
作者：
Finotto, S;Mekori, YA;Metcalfe, DD
通讯作者：
Metcalfe, DD
影响因子：
2.8
作者：
Barreto, ED;Carvalho, VD;Sílva, PMRE
通讯作者：
Sílva, PMRE
影响因子：
7.7
作者：
BOLLINENI, JS;REDDI, AS
通讯作者：
REDDI, AS