Association Between Lower Urinary Tract Symptoms and Frailty in Older Men Presenting for Urologic Care.
Association Between Lower Urinary Tract Symptoms and Frailty in Older Men Presenting for Urologic Care.
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DOI：
10.1016/j.urology.2020.09.041
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发表时间：
2021-03
期刊：
影响因子：
2.1
通讯作者：
Suskind AM
中科院分区：
文献类型：
--
作者：
Bauer SR;Jin C;Kamal P;Suskind AM
评估寻求治疗的老年男性中非神经源性下尿路症状(LUTS)与虚弱之间的关系。这是一项横断面研究，研究对象为65岁及以上的男性患者，他们在2015年12月至2019年3月期间参加了一项学术泌尿外科实践。患有癌症、神经系统疾病、留置尿管或持续渗漏的男性被排除在外。参与者完成了计时起跑测试，该测试用于将男性分为快(≤10s)、中(11-14s)或慢(≥15s)。使用从电子医疗记录中提取的帐单代码来识别具有以下诊断的参与者：膀胱过度活动(OAB)、良性前列腺增生症(BPH)、OAB/BPH混合性疾病或非LUTS泌尿系疾病。使用根据年龄、种族和BMI调整后的多项Logistic回归模型来评估多变量相关性。在我们调查的2 206名男性中，为快(平均时间：8.3±1.2秒)，25%为中等(平均时间：12.0±1.0秒)，11%为慢(平均时间：18.5±4.7秒)。TUGT时间较慢的受试者更有可能是年龄较大、非白人和患有下尿路感染的人。与非LUTS相比，OAB(优势比(OR)=2.62，95%CI为1.74，3.93)、BPH(OR=1.70，95%1.14，2.55)、混合OAB/BPH(OR=1.82，95%1.14，2.92)均与TUGT时间延长有关。LUTS的诊断与TUGT的中位时间无显著相关性。与非LUTS相比，LUTS的诊断，特别是OAB，与缓慢的TUGT时间的几率增加有关，而TUGT时间是脆弱的替代。虚弱在患有LUTS的老年男性中很常见，应该在最初的泌尿学评估中考虑到。
To evaluate the association between non-neurogenic lower urinary tract symptoms (LUTS) and frailty among treatment-seeking older men. This is a cross-sectional study of male patients age 65 years and older presenting to an academic urology practice between December 2015 and March 2019. Men with cancer, neurologic disease, indwelling catheter, or continuous leakage were excluded. Participants completed a Timed-Up-and-Go-Test (TUGT) which was used to categorize men as fast (≤10s), intermediate (11-14s), or slow (≥15s). Participants with the following diagnoses were identified using billing codes extracted from the electronic medical record: overactive bladder (OAB), benign prostatic hyperplasia (BPH), mixed OAB/BPH, or non-LUTS urologic condition. Multivariable associations were evaluated using multinomial logistic regression models adjusted for age, race, and BMI. Among 2206 men included in our sample, 64% were fast (mean TUGT time: 8.3±1.2 seconds), 25% were intermediate (mean TUGT time: 12.0±1.0 seconds), and 11% were slow (mean TUGT time: 18.5±4.7 seconds). Subjects with slow TUGT times were more likely to be older, non-White, and have LUTS. Compared to non-LUTS conditions, OAB (odds ratio (OR)=2.62, 95% CI 1.74, 3.93), BPH (OR=1.70, 95% 1.14, 2.55), and mixed OAB/BPH (OR=1.82, 95% 1.14, 2.92) were all associated with increased odds of slow TUGT time. LUTS diagnosis was not significantly associated with intermediate TUGT time. LUTS diagnosis, particularly OAB, is associated with increased odds of slow TUGT time, a surrogate of frailty, compared to non-LUTS conditions. Frailty is common among older men with LUTS and should be considered during the initial urological evaluation.
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作者：
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通讯作者：
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影响因子：
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作者：
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DOI：
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发表时间：
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影响因子：
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DOI：
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发表时间：
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