Nucleolus Modulates the Shuttle of Telomere Components between Nucleolus and Telomere
Nucleolus Modulates the Shuttle of Telomere Components between Nucleolus and Telomere
复制标题
核仁调节核仁和端粒之间端粒成分的穿梭
DOI：
10.35248/2684-1258.18.4.136
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
童坦君
中科院分区：
文献类型：
--
作者：
袁富文;童坦君
Nucleolus was first described about two centuries ago, functioning as the factory of rRNA transcription, processing and assembly of ribosome. While recently studied reported that it can also participate in other bioprocesses such as cell cycle arrest, cellular senescence, protein sub-nuclear distribution and cancer cell proliferation, except its ribosome role. Shelterin as well telomerase is critical for the integration and length maintenance. Here are some studies found that some telomere components like telomere was also accumulated in nucleolus and its retention in nucleolus was regulated by nucleolus protein which is indispensable for the matured of telomerase. Our recent study also demonstrated that TRF2, a member of shelterin, also settled in nucleolus and its telomere protection function was affected by the shuttling between nucleolus and telomere. Here, we review the recent research on the communication between nucleolus and telomere with emphasis on the potential and valuable research direction.
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DOI：
10.4161/cc.8.18.9543
发表时间：
2009-09-15
期刊：
Cell cycle (Georgetown, Tex.)
影响因子：
--
作者：
Tsai RY
通讯作者：
Tsai RY
DOI：
--
发表时间：
1996-07
期刊：
--
影响因子：
--
作者：
M. Thiry;G. Goessens
通讯作者：
M. Thiry;G. Goessens
核仁和卷曲体磷蛋白 1 (NOLC1) 调节 TRF2 的核仁保留
影响因子：
7
作者：
Yuan F;Li G;Tong T
通讯作者：
Tong T
影响因子：
7.5
作者：
MELESE, T;XUE, Z
通讯作者：
XUE, Z
影响因子：
14.9
作者：
Pederson, T
通讯作者：
Pederson, T