Early life stress, prenatal secondhand smoke exposure, and the development of internalizing symptoms across childhood.
Early life stress, prenatal secondhand smoke exposure, and the development of internalizing symptoms across childhood.
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DOI：
10.1186/s12940-023-01012-8
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发表时间：
2023-08-25
影响因子：
6
通讯作者：
Margolis, Amy E.
中科院分区：
文献类型：
--
作者：
DeSerisy, Mariah;Cohen, Jacob W.;Dworkin, Jordan D.;Stingone, Jeanette A.;Ramphal, Bruce;Herbstman, Julie B.;Pagliaccio, David;Margolis, Amy E.
先前关于二手烟草烟雾暴露和以焦虑和抑郁症状加重为特征的内化问题的研究结果是模棱两可的；SHS对神经发育的影响可能取决于其他神经毒物的存在。早期生活压力（ELS）是内化症状的已知危险因素，也经常与SHS暴露同时发生。迄今为止，ELS和SHS对儿童内化症状的相互作用尚不清楚。我们假设，同时暴露于产前SHS和ELS的儿童在学龄前期间内化症状最多，随着时间的推移症状减轻最慢。本研究利用了1998年至2006年间招募的564名黑人和拉丁裔母亲及其子女的前瞻性纵向出生队列。出生时从脐带和母亲血液中提取的可替宁作为产前SHS暴露的生物标志物。父母报告的儿童行为检查表（CBCL）得分在学龄前至11岁之间的四个时间点进行检查。ELS暴露是根据5岁儿童报告的6个母亲压力域的组合来测量的。潜在生长模型检验了SHS、ELS及其相互作用期与儿童内化症状轨迹之间的关系。在随访分析中，加权五分位数和回归检验了ELS混合物各成分在每个时间点对儿童内化症状的贡献。ELS与SHS暴露相互作用，较高水平的ELS和SHS暴露与学龄前时期更多的内化症状相关（β = 0.14, p = 0.03）。ELS和SHS之间的相互作用也与内化症状随时间的负变化率较低相关（β=-0.02, p = 0.01）。加权五分位数和回归显示，在每个年龄点，母亲士气低落和压力混合物的其他成分对儿童的内化问题有显著贡献（例如，11岁WQS β = 0.26, p < 0.01）。我们的研究结果表明，先前关于SHS对行为的研究的不一致可能源于未测量的因素，这些因素也会影响行为，并与暴露共同发生，特别是儿童早期生活中的母亲压力。研究结果指出了个性化预防的可修改目标。在线版本包含补充材料，可在10.1186/s12940-023-01012-8获得。
Prior findings relating secondhand tobacco smoke (SHS) exposure and internalizing problems, characterized by heightened anxiety and depression symptoms, have been equivocal; effects of SHS on neurodevelopment may depend on the presence of other neurotoxicants. Early life stress (ELS) is a known risk factor for internalizing symptoms and is also often concurrent with SHS exposure. To date the interactive effects of ELS and SHS on children’s internalizing symptoms are unknown. We hypothesize that children with higher exposure to both prenatal SHS and ELS will have the most internalizing symptoms during the preschool period and the slowest reductions in symptoms over time. The present study leveraged a prospective, longitudinal birth cohort of 564 Black and Latinx mothers and their children, recruited between 1998 and 2006. Cotinine extracted from cord and maternal blood at birth served as a biomarker of prenatal SHS exposure. Parent-reported Child Behavior Checklist (CBCL) scores were examined at four timepoints between preschool and eleven years-old. ELS exposure was measured as a composite of six domains of maternal stress reported at child age five. Latent growth models examined associations between SHS, ELS, and their interaction term with trajectories of children’s internalizing symptoms. In follow-up analyses, weighted quintile sum regression examined contributions of components of the ELS mixture to children’s internalizing symptoms at each time point. ELS interacted with SHS exposure such that higher levels of ELS and SHS exposure were associated with more internalizing symptoms during the preschool period (β = 0.14, p = 0.03). The interaction between ELS and SHS was also associated with a less negative rate of change in internalizing symptoms over time (β=-0.02, p = 0.01). Weighted quintile sum regression revealed significant contributions of maternal demoralization and other components of the stress mixture to children’s internalizing problems at each age point (e.g., age 11 WQS β = 0.26, p < 0.01). Our results suggest that prior inconsistencies in studies of SHS on behavior may derive from unmeasured factors that also influence behavior and co-occur with exposure, specifically maternal stress during children’s early life. Findings point to modifiable targets for personalized prevention. The online version contains supplementary material available at 10.1186/s12940-023-01012-8.
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影响因子：
5
作者：
COHEN, S;KAMARCK, T;MERMELSTEIN, R
通讯作者：
MERMELSTEIN, R
对年轻母亲的育儿同伴教育干预措施对五岁以下儿童的成长和发展的影响。
DOI：
10.3390/children10020338
发表时间：
2023-02-09
期刊：
Children (Basel, Switzerland)
影响因子：
--
作者：
通讯作者：
--
影响因子：
9.1
作者：
Barr AB;Simons LG;Simons RL;Beach SRH;Philibert RA
通讯作者：
Philibert RA
影响因子：
8
作者：
Chung, EK;McCollum, KF;Culhane, JF
通讯作者：
Culhane, JF
影响因子：
7.7
作者：
Bloomfield, Michael A. P.;McCutcheon, Robert A.;Howes, Oliver
通讯作者：
Howes, Oliver