Investigating the inverse association between glycaemia and abdominal aortic dilatation in a large Chinese hypertensive population: a cross-sectional study.
Investigating the inverse association between glycaemia and abdominal aortic dilatation in a large Chinese hypertensive population: a cross-sectional study.
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DOI：
10.21037/atm-22-1256
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发表时间：
2022-04
影响因子：
--
通讯作者：
Guo, Wei
中科院分区：
文献类型：
--
作者：
Zhang, Simeng;Liu, Jie;Jia, Xin;Zhang, Tao;Qin, Xianhui;Jia, Senhao;Li, Yue;Liu, Lishun;Song, Yuxiang;Zuo, Shangwei;Wei, Ren;Duan, Chen;Wu, Zhongyin;Ge, Yangyang;Wang, Xian;Kong, Wei;Xu, Xiping;Wang, Qiang;Huo, Yong;Guo, Wei
有流行病学证据表明，糖尿病对腹主动脉瘤（AAA）的发生和发展具有保护作用。然而，关于葡萄糖水平对腹主动脉直径的作用的信息有限。本研究旨在评估中国高血压人群的空腹血糖（FPG）与肾下主动脉直径之间的关系。前瞻性参与者包括来自两项关于中国高血压临床表现和管理的大型人群研究的候选人。该研究总共纳入了 18,034 名高血压参与者（6,942 名男性和 11,092 名女性，平均年龄为 64.72±7.41 岁）。通过超声扫描测量肾下主动脉的最大直径。进行多变量线性回归分析以评估 FPG 与腹主动脉直径之间的具体关联。基线协变量和主动脉直径之间的交互项用于确定变量是否影响 FPG 和腹主动脉直径之间的关联。其中，有 22 例 AAA 病例被确诊，患有 AAA 的患者糖尿病患病率低于未患有 AAA 的患者。两性的 FPG 和主动脉直径之间也存在显着的负相关。还观察到主动脉直径四分位数的糖尿病患病率呈剂量依赖性下降，与底部四分位数相比，顶部四分位数男性的估计比值比 (OR) 为 0.60（95% CI：0.50-0.72），女性为 0.72（95% CI：0.63-0.82）。吸烟仅与女性 FPG 水平和主动脉直径之间的关联存在交互作用。该关联与其他亚组没有差异。我们的研究结果表明，血糖可能在中国高血压人群中男女主动脉扩张的早期阶段发挥保护作用。需要进行前瞻性研究来证实我们的发现并探索不同人群中这种关联的机制。
There is epidemiological evidence that diabetes has a protective effect on the occurrence and development of abdominal aortic aneurysms (AAAs). However, information on the role of glucose level on abdominal aortic diameter is limited. This study sought to assess the relationship between fasting plasma glucose (FPG) and infra-renal aortic diameter in a Chinese hypertensive population. The prospective participants comprised candidates from 2 large population-based studies on the clinical presentation and management of hypertension in China. In total, 18,034 hypertensive participants (6,942 male and 11,092 females, with a mean age of 64.72±7.41 years) were included in the study. The maximal diameter of the infra-renal aorta was measured by ultrasound scanning. Multivariate linear regression analyses were conducted to assess the specific association between FPG and abdominal aortic diameter. The interaction terms between the baseline covariables and the aortic diameter were used to determine if a variable affected the association between FPG and abdominal aortic diameter. Of these, 22 cases of AAA were identified, and the prevalence of diabetes was lower in those with AAA than those without. A significant negative association was also found between FPG and aortic diameter in both sexes. A dose-dependent decrease in the prevalence of diabetes across quartiles of aortic diameter was also observed, with an estimated odds ratio (OR) of 0.60 (95% CI: 0.50–0.72) for men and 0.72 (95% CI: 0.63–0.82) for women for the top quartiles compared to the bottom quartiles. Cigarette smoking only interacted with the association between FPG level and aortic diameter in women. The association did not differ with other subgroups. Our findings indicate that glycaemia may plays a protective role in the early stage of aortic dilatation in both sexes in a Chinese hypertensive population. Prospective studies need to be conducted to confirm our findings and explore the mechanism underlying this association in different populations.
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作者：
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DOI：
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