Causal role for the primate superior colliculus in the computation of evidence for perceptual decisions.
Causal role for the primate superior colliculus in the computation of evidence for perceptual decisions.
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DOI：
10.1038/s41593-021-00878-6
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发表时间：
2021-08
影响因子：
25
通讯作者：
Basso MA
中科院分区：
文献类型：
--
作者：
Jun EJ;Bautista AR;Nunez MD;Allen DC;Tak JH;Alvarez E;Basso MA
训练有素的猴子进行了两个选择的知觉决策任务，他们报告了感知方向的动态玻璃图案，之前和之后的单方面，可逆的，灭活的脑干区域参与准备眼球运动，上级丘（SC）。令人惊讶的是，我们发现，单方面SC失活产生显着的决策偏差和反应时间的变化与灵长类SC在感知决策中的因果作用一致。拟合信号检测理论和序贯采样模型的数据显示，SC失活产生的对侧决策的相对证据减少，如果增加一个恒定的偏移量随时间变化的证据信号的同侧的选择。这些结果为感知决策的具体认知模型提供了因果证据，并提供了令人信服的证据表明，灵长类动物的SC（脑干结构）在如何计算决策证据方面发挥着因果作用，这一过程通常归因于前脑。
Trained monkeys performed a two-choice perceptual decision-making task in which they reported the perceived orientation of a dynamic Glass pattern, before and after unilateral, reversible, inactivation of a brainstem area involved in preparing eye movements, the superior colliculus (SC). Surprisingly, we found that unilateral SC inactivation produced significant decision biases and changes in reaction times consistent with a causal role for the primate SC in perceptual decision-making. Fitting signal detection theory and sequential sampling models to the data revealed that SC inactivation produced a decrease in the relative evidence for contralateral decisions, as if adding a constant offset to a time-varying evidence signal for the ipsilateral choice. The results provide causal evidence for an embodied cognition model of perceptual decision-making and provide compelling evidence that the SC of primates, a brainstem structure, plays a causal role in how evidence is computed for decisions, a process usually attributed to the forebrain.
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影响因子：
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作者：
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通讯作者：
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