Molecular mechanisms of pharmaconutrients.
Molecular mechanisms of pharmaconutrients.
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DOI：
10.1016/j.jss.2009.06.024
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发表时间：
2010-06-15
期刊：
影响因子：
--
通讯作者：
Kozar RA
中科院分区：
文献类型：
--
作者：
Santora R;Kozar RA
营养补充已成为危重患者管理的标准护理。传统上，营养支持在这一患者群体的目的是补充底物不足继发于应激诱导catastrophic。认识到某些营养素对重症患者的免疫和炎症反应的影响，导致了更复杂的营养策略和概念的发展。大多数研究表明，补充谷氨酰胺、精氨酸、ω-3脂肪酸和核苷酸组合的免疫增强配方的施用可以减少感染性结果。最近，将营养支持与提供关键营养素分开，使得人们进一步认识到分离的营养素（如谷氨酰胺和抗氧化剂）的免疫调节和抗炎益处。这篇文章的目的是审查的分子机制，是独特的每一类经常使用的营养素。更好地了解免疫营养素的特定分子靶点将有助于在危重患者中应用更精细的营养疗法。
Nutritional supplementation has become the standard of care for management of critically ill patients. Traditionally, nutritional support in this patient population was intended to replete substrate deficiencies secondary to stress-induced catabolism. Recognition of the influence of certain nutrients on the immune and inflammatory response of the critically ill has led to the evolution of more sophisticated nutritional strategies and concepts. Administration of immune-enhancing formulas supplemented with a combination of glutamine, arginine, omega-3 fatty acids and nucleotides have been shown in most studies to reduce infectious outcomes. More recently, the separation of nutritional support from the provision of key nutrients, has led to a further appreciation of the immunomodulatory and anti-inflammatory benefits of isolated nutrients, such as glutamine and antioxidants. The purpose of this article is to review the molecular mechanisms that are unique to each class of frequently utilized nutrients. A better understanding of the specific molecular targets of immunonutrients will facilitate application of more refined nutritional therapies in critically ill patients.
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影响因子：
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