Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer.
Mast cell plasticity and sphingosine-1-phosphate in immunity, inflammation and cancer.
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DOI：
10.1016/j.molimm.2014.03.018
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发表时间：
2015-01
影响因子：
3.6
通讯作者：
Oskeritzian CA
中科院分区：
文献类型：
--
作者：
Oskeritzian CA
肥大细胞（MC）在稳态的所有血管组织中都发现，直到最近，仅将其视为通过程度的效应细胞，即通过程度的效应细胞，即MC释放介质的规范过程，包括组胺和预成型蛋白酶和细胞因子，例如特定的抗原（Ag）触发了tnf其他人则报道了由ATP结合盒（ABC）转运蛋白（即，MC Horizon abtermity vansporters）报道了有影响力的多方面鞘脂介质，鞘氨醇1-磷酸盐（S1P），它通过ATP结合盒（ABC）转运蛋白（即，MC Horization navermination the Mc Horization the Mc Horization ivallation the Mc the MC）运输。通过发现其独特的能力，可以选择性地释放介质，这取决于涉及的刺激和接收器。分散的脱粒，这是一个较慢的过程，在此过程中，介质释放发生了较小的形态变化。 。
Mast cells (MC) are found in all vascularized tissues at homeostasis and, until recently, were viewed only as effector cells of allergic reactions via degranulation, the canonical process through which MC release mediators, including histamine and pre-formed proteases and cytokines such as TNF. Cross-linking of IgE bound to surface high affinity receptors for IgE (FcεRI) by a specific antigen (Ag) triggers signaling events leading to degranulation. We and others have reported the concomitant production and export of an influential multifaceted sphingolipid mediator, sphingosine-1-phosphate (S1P) transported outside of MC by ATP-binding cassettes (ABC) transporters, i.e., independently of degranulation. Indeed, the MC horizon expanded by the discovery of their unique ability to selectively release mediators depending upon the stimulus and receptors involved. Aside from degranulation and transporter usage, MC are also endowed with piecemeal degranulation, a slower process during which mediator release occurs with minor morphological changes. The broad spectrum of pro- and anti-inflammatory bioactive substances MC produce and release, their amounts and delivery pace render these cells bona fide fine-tuners of the immune response. In this viewpoint article, MC developmental, phenotypic and functional plasticity, its modulation by microRNAs and its relevance to immunity, inflammation and cancer will be discussed.
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DOI：
10.4049/jimmunol.0904177
发表时间：
2010-06-01
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Collington SJ;Hallgren J;Pease JE;Jones TG;Rollins BJ;Westwick J;Austen KF;Williams TJ;Gurish MF;Weller CL
通讯作者：
Weller CL
影响因子：
4.4
作者：
Fajardo, I;Pejler, G
通讯作者：
Pejler, G
DOI：
10.1038/nri3494
发表时间：
2013-09
期刊：
Nature reviews. Immunology
影响因子：
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作者：
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DOI：
10.1111/j.1600-6143.2009.02755.x
发表时间：
2009-10
期刊：
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
影响因子：
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作者：
de Vries VC;Wasiuk A;Bennett KA;Benson MJ;Elgueta R;Waldschmidt TJ;Noelle RJ
通讯作者：
Noelle RJ
DOI：
10.1038/nri2782
发表时间：
2010-06
期刊：
Nature reviews. Immunology
影响因子：
--
作者：
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