Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study.
Retinal Venular Tortuosity Jointly with Retinal Amyloid Burden Correlates with Verbal Memory Loss: A Pilot Study.
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DOI：
10.3390/cells10112926
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发表时间：
2021-10-28
期刊：
影响因子：
6
通讯作者：
Koronyo-Hamaoui M
中科院分区：
文献类型：
--
作者：
Dumitrascu OM;Rosenberry R;Sherman DS;Khansari MM;Sheyn J;Torbati T;Sherzai A;Sherzai D;Johnson KO;Czeszynski AD;Verdooner S;Black KL;Frautschy S;Lyden PD;Shi Y;Cheng S;Koronyo Y;Koronyo-Hamaoui M
简介：视网膜成像是一种研究视网膜血管和神经变性的非侵入性工具。在这项探索性视网膜姜黄素荧光成像（RFI）研究中，我们试图确定视网膜血管特征与视网膜淀粉样蛋白负荷是否与神经认知状态相关。方法：我们在一组认知障碍患者中使用定量RFI自动计算视网膜淀粉样蛋白负荷。对视网膜血管进行分割，并对血管迂曲指数（VTI）、弯曲指数和分支角度进行量化。我们使用线性回归模型评估视网膜血管和淀粉样蛋白参数与认知领域Z分数之间的相关性。结果如下：34例受试者入组，29例（55%女性，平均年龄64 ± 6岁）纳入视网膜淀粉样蛋白和血管联合分析。11名受试者认知正常，18名认知受损。视网膜VTI在认知评分中有区别。近端中周淀粉样蛋白计数和静脉VTI指数在认知受损和认知正常受试者之间显示出显著差异（0.49 ± 1.1 vs. 0.91 ± 1.4，p = 0.006），并与韦氏记忆量表-IV和SF-36精神成分评分Z评分相关（p < 0.05）。结论：这项初步研究表明，视网膜小静脉VTI结合近端中周边淀粉样蛋白计数可以预测言语记忆丧失。未来的研究需要精细化这种基于视网膜成像的技术的临床应用。
Introduction: Retinal imaging is a non-invasive tool to study both retinal vasculature and neurodegeneration. In this exploratory retinal curcumin-fluorescence imaging (RFI) study, we sought to determine whether retinal vascular features combined with retinal amyloid burden correlate with the neurocognitive status. Methods: We used quantitative RFI in a cohort of patients with cognitive impairment to automatically compute retinal amyloid burden. Retinal blood vessels were segmented, and the vessel tortuosity index (VTI), inflection index, and branching angle were quantified. We assessed the correlations between retinal vascular and amyloid parameters, and cognitive domain Z-scores using linear regression models. Results: Thirty-four subjects were enrolled and twenty-nine (55% female, mean age 64 ± 6 years) were included in the combined retinal amyloid and vascular analysis. Eleven subjects had normal cognition and 18 had impaired cognition. Retinal VTI was discriminated among cognitive scores. The combined proximal mid-periphery amyloid count and venous VTI index exhibited significant differences between cognitively impaired and cognitively normal subjects (0.49 ± 1.1 vs. 0.91 ± 1.4, p = 0.006), and correlated with both the Wechsler Memory Scale-IV and SF-36 mental component score Z-scores (p < 0.05). Conclusion: This pilot study showed that retinal venular VTI combined with the proximal mid-periphery amyloid count could predict verbal memory loss. Future research is needed to finesse the clinical application of this retinal imaging-based technology.
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影响因子：
14
作者：
通讯作者：
--
影响因子：
4.3
作者：
Grimaldi, Alfonso;Pediconi, Natalia;Di Angelantonio, Silvia
通讯作者：
Di Angelantonio, Silvia
DOI：
10.1002/dad2.12026
发表时间：
2020-01-01
影响因子：
5.3
作者：
Allegri, Ricardo F.;Chrem Mendez, Patricio;Sevlever, Gustavo
通讯作者：
Sevlever, Gustavo
DOI：
10.1002/dad2.12053
发表时间：
2020-01-01
影响因子：
5.3
作者：
Carare, Roxana O.;Aldea, Roxana;Verma, Ajay
通讯作者：
Verma, Ajay
影响因子：
2.1
作者：
Frost, Shaun;Bhuiyan, Alauddin;Kanagasingam, Yogesan
通讯作者：
Kanagasingam, Yogesan