Antinuclear Antibodies Are Associated with an Increased Risk of Diffuse Large B-Cell Lymphoma.
Antinuclear Antibodies Are Associated with an Increased Risk of Diffuse Large B-Cell Lymphoma.
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DOI：
10.3390/cancers15215231
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发表时间：
2023-10-31
期刊：
影响因子：
5.2
通讯作者：
Berndt, Sonja I.
中科院分区：
文献类型：
--
作者：
Frost, Eleanor;Hofmann, Jonathan N.;Huang, Wen-Yi;Parks, Christine G.;Frazer-Abel, Ashley A.;Deane, Kevin D.;Berndt, Sonja I.
关键词：
一些自身免疫性疾病与非霍奇金淋巴瘤(NHL)风险增加有关，但不同亚型的NHL证据不同，很少有研究检验自身免疫是否更普遍地与疾病风险有关。鉴于在美国，随着时间的推移，通过抗核抗体(ANA)来衡量自身免疫力的上升，评估其与NHL风险的潜在关联是很重要的。在这项嵌套式病例对照研究中，我们测量了ANA和其他自身免疫生物标记物在病例和对照诊断前几年收集的血清中的含量。我们证明，ANA的存在与弥漫性大B细胞淋巴瘤的风险增加有关，弥漫性大B细胞淋巴瘤是非霍奇金淋巴瘤的一种常见亚型。我们进一步表明，特定的自身免疫生物标记物与NHL风险的增加有关，特别是弥漫性大B细胞和边缘区淋巴瘤。我们的研究确定自身免疫是弥漫性大B细胞淋巴瘤的危险因素。免疫失调被认为会增加患非霍奇金淋巴瘤(NHL)的风险，但证据因亚型而异。在一项嵌套式病例对照研究中，我们评估了抗核抗体(ANA)、双链DNA抗体(抗dsDNA)和可提取核抗原抗体(抗ENA)是否与常见NHL亚型的风险相关。从前列腺癌、肺癌、结直肠癌和卵巢癌筛查试验中收集的832例患者和809名对照的血清中检测了NHL诊断前几年的自身抗体。Logistic回归用于确定与NHL风险相关的优势比(OR)和95%可信区间(95%CI)。未发现ANA阳性与NHL总体风险相关(OR：1.18，95%CI：0.88~1.58)；然而，ANA阳性与弥漫性大B细胞淋巴瘤(DLBCL)的风险增加相关(OR：1.83，95%CI：1.15~2.91)，19.7%的病例和12.2%的对照组检测为阳性。抗ENA抗体或抗dsDNA抗体阳性与非霍奇金淋巴瘤(OR：2.93，95%CI：1.18~7.28)，特别是DLBCL(OR：3.51，95%CI：1.02~12.0)和边缘带淋巴瘤(OR：8.86，95%CI：1.26~62.0)相关。我们的研究表明，自身抗体与DLBCL的风险增加有关，这为自身免疫作为一个危险因素提供了支持。
Some autoimmune diseases have been linked to an increased risk of non-Hodgkin lymphoma (NHL), but the evidence varies across different subtypes of NHL, and few studies have examined whether autoimmunity is more generally associated with disease risk. Given the rise in autoimmunity, as measured by antinuclear antibodies (ANA) over time in the U.S., it is important to evaluate its potential association with NHL risk. In this nested case-control study, we measured ANA and other autoimmune biomarkers in serum collected years prior to diagnosis for cases and controls. We demonstrate that the presence of ANA is associated with an increased risk of diffuse large B-cell lymphoma, a common subtype of non-Hodgkin lymphoma. We further show that specific autoimmune biomarkers are associated with an increased risk of NHL, especially diffuse large B-cell and marginal zone lymphoma. Our study establishes autoimmunity as a risk factor for diffuse large B-cell lymphoma. Immune dysregulation is thought to increase the risk of non-Hodgkin lymphoma (NHL), but the evidence varies by subtype. We evaluated whether antinuclear antibodies (ANA), double-stranded DNA antibodies (anti-dsDNA), and extractable nuclear antigen antibodies (anti-ENA) were associated with the risk of common NHL subtypes in a nested case-control study. The autoantibodies were tested in serum collected years prior to NHL diagnosis in 832 cases and 809 controls from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial. Logistic regression was used to determine odds ratios (ORs) and 95% confidence intervals (95% CI) for the association with NHL risk. No association was observed between ANA positivity and NHL risk overall (OR: 1.18, 95% CI: 0.88–1.58); however, ANA positivity was associated with an increased risk of diffuse large B-cell lymphoma (DLBCL) (OR: 1.83, 95% CI: 1.15–2.91), with 19.7% of cases and 12.2% of controls testing positive. The presence of either anti-ENA or anti-dsDNA was associated with an increased risk of NHL (OR: 2.93, 95% CI: 1.18–7.28), particularly DLBCL (OR: 3.51, 95% CI: 1.02–12.0) and marginal zone lymphoma (OR: 8.86, 95% CI: 1.26–62.0). Our study demonstrates that autoantibodies are associated with an elevated risk of DLBCL, providing support for autoimmunity as a risk factor.
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作者：
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通讯作者：
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发表时间：
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