Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study.
Effect of Vitamin D and Docosahexaenoic Acid Co-Supplementation on Vitamin D Status, Body Composition, and Metabolic Markers in Obese Children: A Randomized, Double Blind, Controlled Study.
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维生素D和二十二碳六烯酸共同补充对肥胖儿童维生素D状态、身体成分和代谢标志物的影响：一项随机、双盲、对照研究。
作者：
肥胖儿童患维生素D缺乏症的风险很高。Omega-3多不饱和脂肪酸及其衍生物可能对肥胖儿童的维生素D状况有有益影响，因为它们具有抗炎作用，并增加维生素D的吸收。这项多中心、随机、双盲对照研究旨在探讨维生素D和二十二碳六烯酸（DHA）共同补充6个月对维生素D缺乏症肥胖儿童维生素D状态、身体成分和代谢指标的影响。共有108名儿童被纳入研究，73名儿童完成了研究：33名儿童补充了500毫克DHA和1200 IU/天的维生素D3口服剂量，41名补充了1200 IU/天的维生素D3 +小麦胚芽油。在研究结束时，超过50%的研究对象的维生素D水平得到了改善。然而，共同补充并不比维生素D加小麦胚芽油更有效。即使在研究结束时所有的受试者仍然肥胖，两组的脂肪质量百分比都显著降低，体重指数也有所改善。同时服用维生素D和DHA的儿童DHA水平的增加幅度更高，这可能与预防炎症相关的肥胖并发症有关，但对维生素D水平没有影响。
Obese children are at high risk of developing vitamin D deficiency. Omega-3 polyunsaturated fatty acids and their derivatives might have a beneficial effect on vitamin D status of obese children, due to their anti-inflammatory action, and increasing its absorption. This multicenter, randomized, double-blind controlled study aims to investigate the effect of vitamin D and docosahexaenoic acid (DHA) co-supplementation for six months on vitamin D status, body composition, and metabolic markers of obese children with vitamin D deficiency. A total of 108 children were enrolled and 73 children completed the study: 33 were supplemented with an oral dose of 500 mg of DHA and 1200 IU/day of vitamin D3 and 41 were supplemented with 1200 IU/day of vitamin D3 + wheat germ oil. At the end of the study, more than 50% of the subjects improved their vitamin D status. However, co-supplementation was not more effective than vitamin D plus wheat germ oil. Fat mass percentage was significantly reduced, and body mass index improved in both groups, even if all the subjects were still obese at the end of the study. Children receiving both vitamin D and DHA presented a higher increase of DHA levels that could be relevant to prevent inflammatory-associated complications of obesity, but they had no effect on vitamin D levels.
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影响因子：
3.2
作者：
Aguirre Castaneda R;Nader N;Weaver A;Singh R;Kumar S
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3
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