Response to vitamin D3 supplementation in obese and non-obese Caucasian adolescents.
Response to vitamin D3 supplementation in obese and non-obese Caucasian adolescents.
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DOI：
10.1159/000343446
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发表时间：
2012
影响因子：
3.2
通讯作者：
Kumar S
中科院分区：
文献类型：
--
作者：
Aguirre Castaneda R;Nader N;Weaver A;Singh R;Kumar S
维生素D缺乏症在肥胖儿童中非常普遍。肥胖儿童往往对维生素D补充反应不佳。该研究的目的是比较肥胖和非肥胖高加索青少年对维生素D3补充剂（2000 IU，每日一次，持续12周）的反应。研究设计为开放标签非随机化。它是在一个中心进行的。18名肥胖青少年（年龄12-18岁）和相同数量的年龄，性别和季节匹配的非肥胖青少年口服维生素D3（2000 IU/天）12周。在基线和12周结束时测量血清总25（OH）D、PTH、钙和磷。非肥胖受试者的平均基线25（OH）D水平高于肥胖受试者（平均值，28.9 vs 25.2 ng/mL，p=0.029）。补充维生素D后，肥胖青少年25（OH）D水平的增加显著降低（平均变化，5.8 vs. 9.8 ng/mL，p=0.019）。治疗肥胖青少年的维生素D缺乏症需要比非肥胖青少年更高剂量的维生素D。
Vitamin D deficiency is highly prevalent in obese children. Obese children tend to respond poorly to vitamin D supplementation. The objective of the study was to compare the response to vitamin D3 supplementation (2000 IU once daily for 12 weeks) between obese and non- obese Caucasian adolescents. The study design was open label non-randomized. It was carried out at a single center. Eighteen obese adolescents (age 12-18 years) and the same number of age, gender and season matched non-obese adolescents received Vitamin D3 (2000 IU/day) orally for 12 weeks. Total serum 25(OH) D, PTH, calcium and phosphorus were measured at baseline and at the end of the 12 week period. The mean baseline 25 (OH)D level was higher in the non-obese subjects compared to the obese subjects (mean, 28.9 vs. 25.2 ng/mL, p=0.029). The increment in 25(OH) D levels following vitamin D supplementation was significantly lower in the obese adolescents (mean change, 5.8 vs. 9.8 ng/mL, p=0.019). Higher doses of vitamin D are required to treat vitamin D deficiency in obese adolescents than in their non-obese peers.
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影响因子：
16.2
作者：
Scragg, R;Sowers, M;Bell, C
通讯作者：
Bell, C
影响因子：
9.8
作者：
Alemzadeh, Ramin;Kichler, Jessica;Calhoun, Mariaelena
通讯作者：
Calhoun, Mariaelena
影响因子：
5.8
作者：
Holick, MF;Siris, ES;de Papp, AE
通讯作者：
de Papp, AE
影响因子：
--
作者：
Sullivan, SS;Rosen, CJ;Holick, MF
通讯作者：
Holick, MF
影响因子：
5.8
作者：
Rajakumar, Kumaravel;de Las Heras, Javier;Arslanian, Silva A.
通讯作者：
Arslanian, Silva A.