Integrating Narcissus-derived galanthamine production into traditional upland farming systems.
Integrating Narcissus-derived galanthamine production into traditional upland farming systems.
复制标题
将水仙衍生加兰他敏生产纳入传统的高地耕作系统。
DOI：
10.1038/s41598-021-81042-9
复制
发表时间：
2021-01-14
影响因子：
4.6
通讯作者：
Chang X
中科院分区：
文献类型：
--
作者：
Fraser MD;Vallin HE;Davies JRT;Rowlands GE;Chang X
阿尔茨海默病(AD)是一种与记忆和认知功能进行性退化有关的疾病。加兰他明是一种获得许可的治疗阿尔茨海默病的药物，但生产加兰他明的植物生物碱的供应有限。这项为期三年的系统研究测试了将水仙衍生的加兰他明生产与草原反刍动物生产相结合的可能性。准备了永久草地的重复小区，有和没有水仙鳞茎作为线条播种到草地上。实行了两种不同的化肥制度。早春采收伪节藻地上部绿色生物量，测定其加兰他明产量。在第二个收获年，采用裂区设计，每年一次和两年一次地砍一次线。所有的地块随后都被母羊和羔羊放牧，并记录了动物的表现。在放牧后的永久牧场中加入拟松材线虫，对随后放牧的绵羊的健康或生产性能没有不利影响。不同施肥量对加兰他明产量的影响没有一致性。如果每两年削减一次，总的加兰他明产量没有差异(每年联合削减与两年一次削减分别为1.64亿公斤加兰他明/公顷和1.75万公斤加兰他明/公顷；s.e.d = 0.117加兰他明/公顷；ns)。本研究验证了一种生产植物源性加兰他明的两熟种植方法的可行性。
Alzheimer’s disease (AD) is a disorder associated with progressive degeneration of memory and cognitive function. Galantamine is a licenced treatment for AD but supplies of the plant alkaloid that it is produced from, galanthamine, are limited. This three-year system study tested the potential to combine Narcissus-derived galanthamine production with grassland-based ruminant production. Replicate plots of permanent pasture were prepared with and without bulbs of Narcissus pseudonarcissus sown as lines into the sward. Two different fertiliser regimes were imposed. The above-ground green biomass of N. pseudonarcissus was harvested in early spring and the galanthamine yield determined. In the second harvest year a split-plot design was implemented with lines of N. pseudonarcissus cut annually and biennially. All plots were subsequently grazed by ewes and lambs and animal performance recorded. Incorporation of N. pseudonarcissus into grazed permanent pasture had no detrimental effects on the health or performance of the sheep which subsequently grazed the pasture. There was no consistency to the effects of fertiliser rates on galanthamine yields. There was no difference in overall galanthamine yield if N. pseudonarcissus was cut biennially (1.64 vs. 1.75 kg galanthamine/ha for annual combined vs biennial cuts respectively; s.e.d = 0.117 kg galanthamine/ha; ns). This study verified the feasibility of a dual cropping approach to producing plant-derived galanthamine.
登录
查看更多内容
DOI：
10.3233/jad-160791
发表时间：
2017
期刊：
Journal of Alzheimer's disease : JAD
影响因子：
--
作者：
Fraser MD;Davies JR;Chang X
通讯作者：
Chang X
石蒜碱：抗癌药物发现的潜在天然先导物质
DOI：
10.1016/j.biopha.2018.07.147
发表时间：
2018-11
期刊：
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie
影响因子：
--
作者：
Roy M;Liang L;Xiao X;Feng P;Ye M;Liu J
通讯作者：
Liu J
DOI：
10.1002/joc.5798
发表时间：
2018-07-01
期刊：
INTERNATIONAL JOURNAL OF CLIMATOLOGY
影响因子：
--
作者：
Kendon, Mike;McCarthy, Mark;Legg, Tim
通讯作者：
Legg, Tim
影响因子：
5.9
作者：
Torras-Claveria, Laura;Berkov, Strahil;Bastida, Jaume
通讯作者：
Bastida, Jaume
影响因子：
5.1
作者：
Havelek, Radim;Muthna, Darina;Rezacova, Martina
通讯作者：
Rezacova, Martina