Carbon Nitride Nanosheets for Imaging Traceable CpG Oligodeoxynucleotide Delivery
Carbon Nitride Nanosheets for Imaging Traceable CpG Oligodeoxynucleotide Delivery
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用于成像可追踪 CpG 寡脱氧核苷酸传递的氮化碳纳米片
DOI：
10.1021/acsanm.1c01658
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发表时间：
2021-08
影响因子：
5.9
通讯作者：
Jinghua Chen
中科院分区：
文献类型：
--
作者：
Huijie Zhang;Airan Ding;Baoting Ye;Zhiqing Wang;Jiawen Zhang;Lipeng Qiu;Jinghua Chen
CpG oligodeoxynucleotides (ODNs) activate TLR9 and show immunostimulatory activity, which are promising in immunotherapy. However, delivery of CpG ODNs into target immune cells and simultaneously tracing their intracellular dynamic process remain a big challenge. Graphitic carbon nitride (GCN) has gained increasing interest in biomedical areas due to its advantageous physicochemical properties, especially its unique optical characteristics. Herein, a multifunctional CpG ODN delivery system was developed utilizing chitosan (CS)-functionalized ultrathin GCN nanosheets (GCNNs). The ultrathin GCNNs with a thickness of about 0.6 nm were synthesized by acid etching and exfoliating the bulk GCN. CS-GCNNs showed no cytotoxicity while exhibiting efficient CpG ODN loading. CS-GCNNs notably increased the cellular uptake of the CpG ODN pathway and thus triggered enhanced immunostimulation. More importantly, CS-GCNNs exhibited adjuvant activity and could stably trace the process of CpG ODN delivery by cell imaging benefiting from their outstanding photoluminescent properties. Taken together, our findings provide an efficient and traceable platform for immunotherapy.
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影响因子：
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