Informing tendon tissue engineering with embryonic development.
Informing tendon tissue engineering with embryonic development.
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DOI：
10.1016/j.jbiomech.2013.12.039
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发表时间：
2014-06-27
影响因子：
2.4
通讯作者：
Kuo, Catherine K.
中科院分区：
文献类型：
--
作者：
Glass, Zachary A.;Schiele, Nathan R.;Kuo, Catherine K.
关键词：
肌腱是一种强大的结缔组织，它将肌肉产生的力量转化为骨骼运动。在履行这一角色时，肌腱受到反复的机械负荷和高应力，这可能导致损伤。干细胞组织工程提供了用健康的、新的活组织代替受伤/受损组织的潜力。肌腱组织工程的关键是诱导和引导干细胞向肌腱表型发展。典型的策略依赖于成体组织稳态和愈合因子来影响干细胞分化，但尚未实现组织再生。一个新的范例是使用胚胎发育因子作为线索来促进肌腱再生。胚胎肌腱祖细胞在体内的分化受机械和化学因素的共同调控。我们提出，这些线索将引导干细胞概括肌腱形成的关键方面，并有效地指导细胞分化和再生新的肌腱。在此，我们回顾了最近在确定胚胎肌腱发育的机械和化学因素以指导干细胞/祖细胞分化形成新肌腱方面的努力，并讨论了这项工作在未来肌腱组织工程中的作用。
Tendon is a strong connective tissue that transduces muscle-generated forces into skeletal motion. In fulfilling this role, tendons are subjected to repeated mechanical loading and high stress, which may result in injury. Tissue engineering with stem cells offers the potential to replace injured/damaged tissue with healthy, new living tissue. Critical to tendon tissue engineering is the induction and guidance of stem cells towards the tendon phenotype. Typical strategies have relied on adult tissue homeostatic and healing factors to influence stem cell differentiation, but have yet to achieve tissue regeneration. A novel paradigm is to use embryonic developmental factors as cues to promote tendon regeneration. Embryonic tendon progenitor cell differentiation in vivo is regulated by a combination of mechanical and chemical factors. We propose that these cues will guide stem cells to recapitulate critical aspects of tenogenesis and effectively direct the cells to differentiate and regenerate new tendon. Here, we review recent efforts to identify mechanical and chemical factors of embryonic tendon development to guide stem/progenitor cell differentiation toward new tendon formation, and discuss the role this work may have in the future of tendon tissue engineering.
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