The neural networks underlying auditory sensory gating.
The neural networks underlying auditory sensory gating.
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DOI：
10.1016/j.neuroimage.2008.08.025
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发表时间：
2009-01-01
期刊：
影响因子：
5.7
通讯作者：
Canive JM
中科院分区：
文献类型：
--
作者：
Mayer AR;Hanlon FM;Franco AR;Teshiba TM;Thoma RJ;Clark VP;Canive JM
精神分裂症文献中报道的最一致的电生理缺陷之一是未能抑制或适当地门控对相同对的第二刺激的神经元反应（即，感觉门控）。虽然动物和侵入性人类研究一直暗示听觉皮层，前额叶皮层和海马介导的感觉门控反应，在这些结构中的局部激活并不总是在非侵入性成像模式的报告。在本实验中，事件相关的功能磁共振成像和传统的门控范式的一个变体被用来检查门控网络的差异响应对相同和不相同的音调的处理。还提出了两个单音条件，以便它们可以用于估计成对刺激的HRF，基于实际血流动力学反应重建，以作为控制非门控条件。结果支持了一个新兴的理论，即两个双音条件下的门控反应主要是由听觉和前额叶皮层介导的，与丘脑的潜在贡献。结果还表明，左侧听觉皮层可能发挥优先作用，确定刺激，应被抑制（门控）或接受进一步的处理，由于新奇的信息。相比之下，没有证据表明海马参与，这表明未来的工作需要确定它在门控反应中可能发挥的作用。
One of the most consistent electrophysiological deficits reported in the schizophrenia literature is a failure to inhibit, or properly gate, the neuronal response to the second stimulus of an identical pair (i.e., sensory gating). Although animal and invasive human studies have consistently implicated the auditory cortex, prefrontal cortex and hippocampus in mediating the sensory gating response, localized activation in these structures has not always been reported during non-invasive imaging modalities. In the current experiment, event-related FMRI and a variant of the traditional gating paradigm were utilized to examine how the gating network differentially responded to the processing of pairs of identical and non-identical tones. Two single-tone conditions were also presented so that they could be used to estimate the HRF for paired stimuli, reconstructed based on actual hemodynamic responses, to serve as a control non-gating condition. Results supported an emerging theory that the gating response for both paired-tones conditions was primarily mediated by auditory and prefrontal cortex, with potential contributions from the thalamus. Results also indicated that the left auditory cortex may play a preferential role in determining the stimuli that should be inhibited (gated) or receive further processing due to novelty of information. In contrast, there was no evidence of hippocampal involvement, suggesting that future work is needed to determine what role it may play in the gating response.
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