Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines.
Impact of virus genetic variability and host immunity for the success of COVID-19 vaccines.
复制标题
DOI：
10.1016/j.biopha.2021.111272
复制
发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Dos Santos WG
中科院分区：
文献类型：
--
作者：
Dos Santos WG
冠状病毒疾病19（COVID-19）继续挑战大多数科学家寻找有效方法来预防感染或避免疾病传播。由于全球的努力，我们取得了一些进展，我们今天比大流行病开始时做了更多的准备，但不足以阻止传播，许多问题仍然没有答案。康复者再次感染的可能性、免疫力的持续时间、SARS-CoV-2突变对疾病传播的影响以及潜在疫苗可能具有的保护程度是正在辩论的一些问题。许多疫苗正在使用不同的平台开发，临床试验正在不同的国家进行，但即使获得许可，也需要时间才能得出关于其真实的安全性和有效性的明确结论。在本文中，我们讨论了COVID-19疫苗开发中使用的不同策略，它们可能引发的免疫应答类型的潜在问题，新突变在SARS-CoV-2亚型产生中可能产生的后果，以及它们对大流行后情况下潜在疫苗有效性的影响和挑战。
Coronavirus disease 19 (COVID-19) continues to challenge most scientists in the search of an effective way to either prevent infection or to avoid spreading of the disease. As result of global efforts some advances have been reached and we are more prepared today than we were at the beginning of the pandemic, however not enough to stop the transmission, and many questions remain unanswered. The possibility of reinfection of recovered individuals, the duration of the immunity, the impact of SARS-CoV-2 mutations in the spreading of the disease as well as the degree of protection that a potential vaccine could have are some of the issues under debate. A number of vaccines are under development using different platforms and clinical trials are ongoing in different countries, but even if they are licensed it will need time until reach a definite conclusion about their real safety and efficacy. Herein we discuss the different strategies used in the development of COVID-19 vaccines, the questions underlying the type of immune response they may elicit, the consequences that new mutations may have in the generation of sub-strains of SARS-CoV-2 and their impact and challenges for the efficacy of potential vaccines in a scenario postpandemic.
登录
查看更多内容
影响因子：
12.4
作者：
Dong, Xiang;Cao, Yi-yuan;Gao, Ya-dong
通讯作者：
Gao, Ya-dong
影响因子：
168.9
作者：
Chan, Jasper Fuk-Woo;Yuan, Shuofeng;Yuen, Kwok-Yung
通讯作者：
Yuen, Kwok-Yung
影响因子：
1.9
作者：
Chiappelli, Francesco;Khakshooy, Allen;Greenberg, Gillian
通讯作者：
Greenberg, Gillian
影响因子：
3.7
作者：
Bai, Bingke;Hu, Qinxue;Hu, Hui;Zhou, Peng;Shi, Zhengli;Meng, Jin;Lu, Baojing;Huang, Yi;Mao, Panyong;Wang, Hanzhong
通讯作者：
Wang, Hanzhong
DOI：
10.1073/pnas.90.9.4171
发表时间：
1993-05-01
影响因子：
11.1
作者：
DRAKE, JW
通讯作者：
DRAKE, JW