Multicellular model for intercellular synchronization in circadian neural networks.
Multicellular model for intercellular synchronization in circadian neural networks.
复制标题
昼夜节律神经网络中细胞间同步的多细胞模型。
DOI：
10.1016/j.bpj.2011.04.051
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发表时间：
2011
影响因子：
3.4
通讯作者：
Henson,MichaelA
中科院分区：
文献类型：
--
作者：
Vasalou,Christina;Herzog,ErikD;Henson,MichaelA
We developed a multicellular model characterized by a high degree of heterogeneity to investigate possible mechanisms that underlie circadian network synchronization and rhythmicity in the suprachiasmatic nucleus (SCN). We populated a two-dimensional grid with 400 model neurons coupled viaγ-aminobutyric acid (GABA) and vasoactive intestinal polypeptide (VIP) neurotransmitters through a putative Ca2+mediated signaling cascade to investigate their roles in gene expression and electrical firing activity of cell populations. As observed experimentally, our model predicted that GABA would affect the amplitude of circadian oscillations but not synchrony among individual oscillators. Our model recapitulated experimental findings of decreased synchrony and average periods, loss of rhythmicity, and reduced circadian amplitudes as VIP signaling was eliminated. In addition, simulated increases of VIP reduced periodicity and synchrony. We therefore postulated a physiological range of VIP within which the system is able to produce sustained and synchronized oscillations. Our model recapitulated experimental findings of diminished amplitudes and periodicity with decreasing intracellular Ca2+concentrations, suggesting that such behavior could be due to simultaneous decrease of individual oscillation amplitudes and population synchrony. Simulated increases in Cl−levels resulted in increased Cl−influx into the cytosol, a decrease of inhibitory postsynaptic currents, and ultimately a shift of GABA-elicited responses from inhibitory to excitatory. The simultaneous reduction of IPSCs and increase in membrane resting potential produced GABA dose-dependent increases in firing rates across the population, as has been observed experimentally. By integrating circadian gene regulation and electrophysiology with intracellular and intercellular signaling, we were able to develop the first (to our knowledge) multicellular model that allows the effects of clock genes, electrical firing, Ca2+, GABA, and VIP on circadian system behavior to be predicted.
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DOI：
10.1073/pnas.92.16.7396
发表时间：
1995-08
影响因子：
11.1
作者：
Kazuyuki Shinohara;S. Honma;Y. Katsuno;H. Abe;K. Honma
通讯作者：
Kazuyuki Shinohara;S. Honma;Y. Katsuno;H. Abe;K. Honma
影响因子：
5.3
作者：
Choi, Hee Joo;Lee, C. Justin;Kim, Yang In
通讯作者：
Kim, Yang In
培养大鼠视交叉上神经元昼夜节律的同步
DOI：
--
发表时间：
2000
期刊：
影响因子：
--
作者：
T. Shirakawa;S. Honma;Y. Katsuno;H. Oguchi;K. Honma
通讯作者：
K. Honma
影响因子：
3.4
作者：
Reed, HE;Meyer-Spasche, A;Piggins, HD
通讯作者：
Piggins, HD
影响因子：
2.5
作者：
Itri, J;Colwell, CS
通讯作者：
Colwell, CS