SCID (severe combined immunodeficiency) mice as a new system to investigate metastasis of human tumors.
SCID (severe combined immunodeficiency) mice as a new system to investigate metastasis of human tumors.
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SCID（严重联合免疫缺陷）小鼠作为研究人类肿瘤转移的新系统。
DOI：
10.1269/jrr.31.288
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发表时间：
1990
影响因子：
2
通讯作者：
T. Hamaoka
中科院分区：
文献类型：
--
作者：
T. Nomura;Y. Takahama;T. Hongyo;H. Inohara;H. Takatera;H. Fukushima;Y. Ishii;T. Hamaoka
在T细胞和B细胞功能缺陷的严重联合免疫缺陷（scid）小鼠中，皮下和腹膜内移植后，所有动物的人卵黄囊肿瘤（YST-2）都迅速生长到巨大尺寸，而普通无胸腺裸鼠中只有一半皮下移植且没有腹膜内移植。此外，移植肿瘤在scid小鼠中自发转移至远处器官，如肺、肝、肾、胰腺和脾，而在无胸腺裸鼠中未发现转移。在患有人类经典（典型）精原细胞瘤的 scid 小鼠和 scid-nude（streaker）双突变小鼠中观察到类似的结果，而在无胸腺裸鼠中既不能移植也不能转移。因此，scid小鼠提供了一个宝贵的实验系统来研究转移机制，这是癌症患者最重要和危及生命的问题。
In severe combined immunodeficiency (scid) mice which are deficient in T and B cell functions, human yolk sac tumor (YST-2) grew rapidly to enormous sizes in all of the animals after both subcutaneous and intraperitoneal transplantation, while only half of the subcutaneous and none of the intraperitoneal transplants were accepted in usual athymic nude mice. Furthermore, transplanted tumors metastasized spontaneously to distant organs such as lung, liver, kidney, pancreas, and spleen in scid mice, while metastases were not found in athymic nude mice. Similar results were observed in scid mice and scid-nude (streaker) double mutant mice with human classic (typical) seminoma which has been neither transplantable nor metastatic in athymic nude mice. Thus, scid mice provide an invaluable experimental system to investigate the mechanism of metastasis which is the most important and life-threatening problem in cancer patients.
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影响因子：
11.2
作者：
S. Reddy;D. Piccione;H. Takita;R. Bankert
通讯作者：
S. Reddy;D. Piccione;H. Takita;R. Bankert
影响因子：
56.9
作者：
MCCUNE, JM;NAMIKAWA, R;WEISSMAN, IL
通讯作者：
WEISSMAN, IL
DOI：
--
发表时间：
1985-09
期刊：
The American journal of pathology
影响因子：
--
作者：
R. Custer;G. Bosma;M. Bosma
通讯作者：
R. Custer;G. Bosma;M. Bosma
患有严重联合免疫缺陷病的小鼠淋巴和骨髓组织细胞的功能状态。
DOI：
--
发表时间：
1984
期刊：
Journal of immunology (Baltimore, Md. : 1950)
影响因子：
--
作者：
Dorshkind,K;Keller,GM;Phillips,RA;Miller,RG;Bosma,GC;O'Toole,M;Bosma,MJ
通讯作者：
Bosma,MJ