Cortical Morphometry is Associated with Neuropsychological Function in Healthy 8-Year-Old Children.
Cortical Morphometry is Associated with Neuropsychological Function in Healthy 8-Year-Old Children.
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DOI：
10.1111/jon.12754
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发表时间：
2020-11
期刊：
影响因子：
--
通讯作者：
Ou X
中科院分区：
文献类型：
--
作者：
Li T;McCorkle GS;Williams DK;Badger TM;Ou X
皮质发育对于儿童的神经认知至关重要。在这项研究中，我们评估了正常儿童皮质形态测量的变化如何与多个认知领域的结果差异相关。 8 岁儿童被招募进行脑部 MRI 检查，随后进行一系列神经心理学评估。 MRI 扫描包括 Desikan 图集定义的 34 个区域的皮质形态测量的 3D-T1 加权成像。神经心理学评估包括针对智商的雷诺智力评估量表（RIAS）、针对语言的语言基础临床评估（CELF-4）、针对记忆的儿童记忆量表（CMS）、针对学术技能的大范围成就测试（WRAT-4）以及针对执行功能的执行功能行为评定量表（BRIEF）。使用年龄和性别控制的偏相关分析来评估 MRI 测量的皮质特征（包括不同大脑区域的灰质体积、表面积和皮质厚度）与神经心理学测试分数之间的关系。 RIAS/CELF-4/CMS/WRAT-4/BRIEF 评分与多个脑区的灰质体积、表面积或皮质厚度显着相关（R：[0.38-0.44]，P：[0.005-0.046]）。内侧眶额/腹内侧前额皮质中的灰质体积似乎是整体神经认知的敏感标记，因为它与智商、语言、记忆和执行功能行为显着相关。颞上回和颞上沟岸似乎对反映整体语言功能最敏感，因为它们的皮质特征始终与语言相关的测试分数相关。健康儿童的皮质形态测量与神经心理功能显着相关；某些区域/特征可以充当敏感的成像标记。
Cortical development is essential for children’s neurocognition. In this study we evaluated how variations in cortical morphometry in normal children are associated with outcome differences in multiple domains of cognition. 8-year-old children were recruited for a brain MRI followed by a battery of neuropsychological assessments. The MRI scan included 3D-T1-weighted imaging for cortical morphometry in 34 regions defined by the Desikan atlas. The neuropsychological assessments included the Reynolds Intellectual Assessment Scales (RIAS) for IQ, Clinical Evaluation of Language Fundamentals (CELF-4) for language, Children’s Memory Scale (CMS) for memory, Wide Range Achievement Test (WRAT-4) for academic skills, and Behavior Rating Inventory of Executive Function (BRIEF) for executive functions. The relationships between MRI measured cortical features including gray matter volume, surface area, and cortical thickness for different brain regions and neuropsychological test scores were evaluated using partial correlation analyses controlled for age and sex. RIAS/CELF-4/CMS/WRAT-4/BRIEF scores showed significant correlations (R: [0.38-0.44], P: [0.005-0.046]) with gray matter volume, surface area, or cortical thickness in multiple brain regions. Gray matter volume in the medial orbitofrontal/ventromedial prefrontal cortex appeared to be a sensitive marker for overall neurocognition as it significantly correlated with IQ, language, memory, and executive function behaviors. The superior temporal gyrus and banks of superior temporal sulcus appeared to be most sensitive to reflect overall language function as their cortical features consistently correlated with language-related test scores. Cortical morphometry significantly correlated with neuropsychological function in healthy children; certain regions/features may serve as sensitive imaging markers.
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