A survey of enabling technologies in synthetic biology.
A survey of enabling technologies in synthetic biology.
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DOI：
10.1186/1754-1611-7-13
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发表时间：
2013-05-10
影响因子：
5.6
通讯作者：
Endy D
中科院分区：
文献类型：
--
作者：
Kahl LJ;Endy D
实现合成生物学的建设性应用需要继续开发使能技术以及政策和做法，以确保这些技术仍可用于研究。广义上，合成生物学的使能技术包括任何试剂或方法，它们单独或与相关技术相结合，提供产生任何新的研究工具或应用的手段。由于合成生物学的应用可能包含多项专利发明，因此创建最能促进持续创新的知识产权管理结构将是重要的。监测合成生物学的使能技术将促进对与这些技术相关的产权的系统调查，并有助于形成影响这些技术的使用、监管、专利和许可的政策和做法。我们在从事合成生物学研究的自我认同的从业者社区中进行了一项调查，以获得他们对支持生物系统工程的技术的看法和经验。调查参与者广泛使用和认为可行的技术包括生物部分的公共和私人登记、DNA构建物物理组装的标准方法、基因组数据库、用于搜索、比对、分析和编辑DNA序列的软件工具，以及用于DNA合成和测序的商业服务。支持测量、功能组合和数据交换的标准和方法使用较少，但仍被部分调查参与者认为是可行的。从这项调查汇编的一组使能技术提供了对支持合成生物学创新的众多不同技术的洞察。这些技术中的许多都可以广泛使用，要么是由于属于公有领域，要么是通过非排他性许可等法律工具。获得一些受专利保护的技术不太清楚，这些技术的使用可能受到材料转让协议或其他合同条款的限制。我们预计，随着该领域的进步，被认为能够实现合成生物学的技术将发生变化。通过监测合成生物学的使能技术，并处理影响其开发和使用的政策和做法，我们希望该领域将能够更好地实现其全部潜力。
Realizing constructive applications of synthetic biology requires continued development of enabling technologies as well as policies and practices to ensure these technologies remain accessible for research. Broadly defined, enabling technologies for synthetic biology include any reagent or method that, alone or in combination with associated technologies, provides the means to generate any new research tool or application. Because applications of synthetic biology likely will embody multiple patented inventions, it will be important to create structures for managing intellectual property rights that best promote continued innovation. Monitoring the enabling technologies of synthetic biology will facilitate the systematic investigation of property rights coupled to these technologies and help shape policies and practices that impact the use, regulation, patenting, and licensing of these technologies. We conducted a survey among a self-identifying community of practitioners engaged in synthetic biology research to obtain their opinions and experiences with technologies that support the engineering of biological systems. Technologies widely used and considered enabling by survey participants included public and private registries of biological parts, standard methods for physical assembly of DNA constructs, genomic databases, software tools for search, alignment, analysis, and editing of DNA sequences, and commercial services for DNA synthesis and sequencing. Standards and methods supporting measurement, functional composition, and data exchange were less widely used though still considered enabling by a subset of survey participants. The set of enabling technologies compiled from this survey provide insight into the many and varied technologies that support innovation in synthetic biology. Many of these technologies are widely accessible for use, either by virtue of being in the public domain or through legal tools such as non-exclusive licensing. Access to some patent protected technologies is less clear and use of these technologies may be subject to restrictions imposed by material transfer agreements or other contract terms. We expect the technologies considered enabling for synthetic biology to change as the field advances. By monitoring the enabling technologies of synthetic biology and addressing the policies and practices that impact their development and use, our hope is that the field will be better able to realize its full potential.
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影响因子：
3.7
作者：
Engler, Carola;Kandzia, Romy;Marillonnet, Sylvestre
通讯作者：
Marillonnet, Sylvestre
DOI：
10.1126/science.1191652
发表时间：
2010-10-01
期刊：
Science (New York, N.Y.)
影响因子：
--
作者：
Ajikumar PK;Xiao WH;Tyo KE;Wang Y;Simeon F;Leonard E;Mucha O;Phon TH;Pfeifer B;Stephanopoulos G
通讯作者：
Stephanopoulos G
影响因子：
48
作者：
Gibson, Daniel G.;Young, Lei;Smith, Hamilton O.
通讯作者：
Smith, Hamilton O.
影响因子：
56.9
作者：
Boch, Jens;Scholze, Heidi;Bonas, Ulla
通讯作者：
Bonas, Ulla
影响因子：
56.9
作者：
Church, George M.;Gao, Yuan;Kosuri, Sriram
通讯作者：
Kosuri, Sriram