The roles of monkey M1 neuron classes in movement preparation and execution.
The roles of monkey M1 neuron classes in movement preparation and execution.
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DOI：
10.1152/jn.00892.2011
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发表时间：
2013-08
影响因子：
2.5
通讯作者：
Shenoy KV
中科院分区：
文献类型：
--
作者：
Kaufman MT;Churchland MM;Shenoy KV
运动皮层在准备动作时表现出大量的活动，而手臂在准备过程中保持静止。我们研究了初级运动皮层（M1）中假定的抑制性神经元的亚群是否可能参与准备过程中的“门控”运动输出，同时允许运动过程中的输出。这一假说预测了运动开始前抑制的释放。在两只猴子的M1的数据中，我们没有发现这一假设的证据：很少有神经元在运动过程中表现出明显的停顿，并且这些神经元位于广泛分布的尾端。然后，我们确定了一个亚群可能是丰富的抑制性中间神经元，使用它们的波形形状。我们发现这个亚群的放电率在运动过程中倾向于增加，而不是像M1门控模型预测的那样减少。没有观察到可能实施抑制门的明确子集。与以前的证据对上游抑制机制在前运动皮层，这提供了证据对抑制“门”的运动输出在皮层。相反，似乎必须存在某种其他机制。
The motor cortices exhibit substantial activity while preparing movements, yet the arm remains still during preparation. We investigated whether a subpopulation of presumed inhibitory neurons in primary motor cortex (M1) might be involved in “gating” motor output during preparation, while permitting output during movement. This hypothesis predicts a release of inhibition just before movement onset. In data from M1 of two monkeys, we did not find evidence for this hypothesis: few neurons exhibited a clear pause during movement, and these were at the tail end of a broad distribution. We then identified a subpopulation likely to be enriched for inhibitory interneurons, using their waveform shapes. We found that the firing rates of this subpopulation tended to increase during movement instead of decreasing as predicted by the M1 gating model. No clear subset that might implement an inhibitory gate was observed. Together with previous evidence against upstream inhibitory mechanisms in premotor cortex, this provides evidence against an inhibitory “gate” for motor output in cortex. Instead, it appears that some other mechanism must likely exist.
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影响因子：
--
作者：
Fetz, EE;Perlmutter, SI;Votaw, S
通讯作者：
Votaw, S
影响因子：
2.7
作者：
GODSCHALK, M;LEMON, RN;VANDERSTEEN, J
通讯作者：
VANDERSTEEN, J
影响因子：
5.3
作者：
Cisek, Paul
通讯作者：
Cisek, Paul
影响因子：
2.9
作者：
Dum, RP;Strick, PL
通讯作者：
Strick, PL
影响因子：
16.2
作者：
Churchland, Mark M.;Afshar, Afsheen;Shenoy, Krishna V.
通讯作者：
Shenoy, Krishna V.