Impairment of the visuospatial working memory in the patients with Parkinson's Disease: an fMRI study.
Impairment of the visuospatial working memory in the patients with Parkinson's Disease: an fMRI study.
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帕金森氏病患者的视觉空间工作记忆受损：功能磁共振成像研究。
DOI：
10.1186/s12883-021-02366-7
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发表时间：
2021-09-03
期刊：
影响因子：
2.6
通讯作者：
Matsukawa N
中科院分区：
文献类型：
--
作者：
Kawashima S;Shimizu Y;Ueki Y;Matsukawa N
轻度认知功能障碍(MCI)是帕金森病(PD)患者的常见症状。帕金森病患者认知功能障碍的特点是执行功能(包括工作记忆)和视知觉加工。视觉空间n-back测试的优点是将语言n-back测试中涉及的教育偏见的影响降至最低。此外，它还可以在一次测试中评估视觉空间识别和工作记忆。我们的目的是阐明视觉空间n-back测试作为检测帕金森病患者工作记忆损害的工具的优势。我们招募了28名右利手帕金森病患者(18名男性，10名女性)和12名年龄匹配的健康对照组(HC；7名男性，5名女性)。13例为MCI(PD-MCI)，15例为认知正常PD(PD-CN)。使用功能磁共振成像(FMRI)，我们探索了与PD-MCI组、PD-CN组和HC组的n-back测试成绩相关的特定脑区。0-back测试评估视觉空间识别，而1-back和2-back测试评估视觉空间工作记忆。这项测试的三个负荷进行了组内比较。与HC相比，PD患者在所有n-back测试的正确率方面表现明显较差。在2-Back测试中进行的fMRI分析显示，与HC组相比，PD组双侧背外侧前额叶皮质、额中回(MFG)和顶叶的激活程度降低。相比之下，0-back测试中的fMRI结果仅显示额叶的微小差异。在比较PD-MCI组和PD-CN组的任务绩效时，我们发现PD-MCI组的2-back测验的答对正确率低于PD-CN组。然而，0-back和1-back测试的分数在两组之间没有显著差异。FMRI结果显示，与PD-CN组相比，PD-MCI患者在2-Back试验中额中回(MFG)和顶下小叶(IPL)的激活减少。这项研究报告了PD-MCI患者MFG和IPL的激活减少。这些区域可能与帕金森病患者工作记忆受损的病理生理学有关，这涉及额纹状体网络功能障碍。
Mild cognitive impairment (MCI) is a common symptom in the patients with Parkinson’s disease (PD). The characteristics of cognitive impairment in PD are executive function (including working memory) and visuo-perceptual processing. The visuospatial n-back test has the merit of minimizing the influence of educational biases involved in the verbal n-back test. Furthermore, it can assess both visuospatial recognition and working memory in a single test. We aimed to clarify the advantage of the visuospatial n-back test as a tool for detecting impairments of working memory in PD. We enrolled 28 right-handed patients with PD (18 males, 10 females) and 12 age-matched healthy controls (HC; 7 males, 5 females). Thirteen patients were classified as MCI (PD-MCI), and 15 as cognitively normal PD (PD-CN). Using functional MRI (fMRI), we explored the specific brain regions associated with the performance of the n-back test in the PD-MCI, PD-CN, and HC groups. The 0-back test assesses visuospatial recognition, while the 1-back and 2-back tests assess visuospatial working memory. Group comparisons were performed for three loads of this test. Patients with PD performed significantly worse in terms of the correct answer rates of all n-back tests compared with HC. fMRI analyses performed during the 2-back test revealed reduced activation in the bilateral dorsolateral prefrontal cortex, middle frontal gyrus (MFG), and parietal lobule in the PD group compared with the HC group. In contrast, the fMRI result during the 0-back test showed only a marginal difference in the frontal lobe. On comparisons of task performance between the PD-MCI and PD-CN groups, we found that the correct answer rate in the 2-back test was lower in the PD-MCI group than in the PD-CN group. However, scores of the 0-back and 1-back tests were not significantly different between the two groups. The fMRI findings revealed that activations within the middle frontal gyrus (MFG) and inferior parietal lobule (IPL) during the 2-back test were reduced in the patients with PD-MCI when compared to those with PD-CN. This study reports reduced activation of the MFG and IPL in patients with PD-MCI. These regions may be associated with the pathophysiology of working memory impairment in patients with PD, which involves fronto-striatal network dysfunction.
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影响因子：
9.9
作者：
Aarsland, D;Andersen, K;Kragh-Sorensen, P
通讯作者：
Kragh-Sorensen, P
影响因子：
--
作者：
Petersen, Ronald C.;Roberts, Rosebud O.;Knopman, David S.;Boeve, Bradley F.;Geda, Yonas E.;Ivnik, Robcrt J.;Smith, Glenn E.;Jack, Clifford R., Jr.
通讯作者：
Jack, Clifford R., Jr.
患有轻度认知障碍的初治帕金森病的默认模式网络功能障碍：一项静息态功能磁共振成像研究
影响因子：
4.8
作者：
Hou Y;Yang J;Luo C;Song W;Ou R;Liu W;Gong Q;Shang H
通讯作者：
Shang H
影响因子：
3.7
作者：
Carlson, S;Martinkauppi, S;Aronen, HJ
通讯作者：
Aronen, HJ
影响因子：
11
作者：
Lee, Ji E.;Cho, Kyoo H.;Lee, Phil Hyu
通讯作者：
Lee, Phil Hyu