Mild cognitive impairment: ten years later.

Mild cognitive impairment: ten years later.
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DOI:
10.1001/archneurol.2009.266
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发表时间:
2009-12
影响因子:
--
通讯作者:
Jack, Clifford R., Jr.
Jack, Clifford R., Jr.
中科院分区:
其他
文献类型:
--
作者:
Petersen, Ronald C.;Roberts, Rosebud O.;Knopman, David S.;Boeve, Bradley F.;Geda, Yonas E.;Ivnik, Robcrt J.;Smith, Glenn E.;Jack, Clifford R., Jr.

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在过去的10年里,有一个虚拟爆炸在文献中关于轻度认知障碍的结构。对这一主题的兴趣表明,人们越来越重视对认知障碍(如阿尔茨海默病和其他痴呆症)的早期特征的识别。轻度认知功能障碍是这些疾病最早的临床特征,因此已成为临床、流行病学、神经影像学、生物标志物、神经病理学、疾病机制和临床试验研究的焦点。本次审查总结了已经取得的进展,同时也认识到仍然存在的挑战。
In the past 10 years, there has been a virtual explosion in the literature concerning the construct of mild cognitive impairment. The interest in this topic demonstrates the increasing emphasis on the identification of the earliest features of cognitive disorders such as Alzheimer’s disease and other dementias. Mild cognitive impairment represents the earliest clinical features of these conditions and, hence, has become a focus of clinical, epidemiological, neuroimaging, biomarker, neuropathological, disease mechanism and clinical trials research. This review summarizes the progress that has been made while also recognizing the challenges that remain.
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