Altered perspective-dependent brain activation while viewing hands and associated imitation difficulties in individuals with autism spectrum disorder.
Altered perspective-dependent brain activation while viewing hands and associated imitation difficulties in individuals with autism spectrum disorder.
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DOI：
10.1016/j.nicl.2018.04.030
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Kosaka H
中科院分区：
文献类型：
--
作者：
Okamoto Y;Kitada R;Miyahara M;Kochiyama T;Naruse H;Sadato N;Okazawa H;Kosaka H
自闭症谱系障碍（ASD）患者似乎对自己的身体有独特的意识，这可能与手势互动的困难有关。在典型发育（TD）个体中，身体部位的感知在不同的大脑区域进行处理。例如，已知外侧枕颞皮层（LOTC）的激活取决于视角（即，第一或第三人称视角）和身份（即，自己的vs.另一个人的身体）。在本研究中，我们研究了视角和身份如何影响ASD患者的大脑激活，以及视角和身份依赖性大脑激活如何与手势模仿能力相关。18名患有ASD的年轻人和18名TD个体参加了一项fMRI研究，参与者从第一人称和第三人称的角度观察自己或他人的手。我们研究了ASD患者与视角和身份相关的大脑激活是否改变。此外，我们确定了与ASD患者手势模仿困难相关的大脑区域。在TD组中，与第一人称视角相比，从第三人称视角观察手时，左LOTC被更强烈地激活。在ASD组中，左LOTC的这种透视效应显著减弱。我们还观察到在内侧前额叶皮层（mPFC）的视角效应显着的组间差异。相关分析显示，在ASD患者中，顶下小叶（IPL）和小脑的透视效应与手势模仿能力有关。我们的研究表明，ASD患者的非典型视觉自我识别与LOTC和mPFC中的视角效应改变有关，LOTC和mPFC被认为分别涉及身体和核心自我。此外，ASD患者的手势模仿困难可能与IPL和小脑的激活改变有关，但与LOTC无关。这些发现揭示了共同的和不同的神经机制的非典型的视觉自我身体意识和手势互动的ASD。自闭症谱系障碍（ASD）的自身身体意识和手势技能发生改变。外侧枕颞皮层（LOTC）是身体透视和身份的关键。ASD患者LOTC和内侧前额叶皮层的视角效应发生改变。下顶叶小叶和小脑活动是ASD模仿缺陷的基础。身份和视角障碍可能会改变ASD中的身体-姿势互动。
Individuals with autism spectrum disorder (ASD) appear to have a unique awareness of their own body, which may be associated with difficulties of gestural interaction. In typically developing (TD) individuals, the perception of body parts is processed in various brain regions. For instance, activation of the lateral occipito-temporal cortex (LOTC) is known to depend on perspective (i.e., first- or third-person perspective) and identity (i.e., own vs. another person's body). In the present study, we examined how perspective and identity affect brain activation in individuals with ASD, and how perspective- and identity-dependent brain activation is associated with gestural imitation abilities. Eighteen young adults with ASD and 18 TD individuals participated in an fMRI study in which the participants observed their own or another person's hands from the first- and third-person perspectives. We examined whether the brain activation associated with perspective and identity was altered in individuals with ASD. Furthermore, we identified the brain regions the activity of which correlated with gestural imitation difficulties in individuals with ASD. In the TD group, the left LOTC was more strongly activated by viewing a hand from the third-person perspective compared with the first-person perspective. This perspective effect in the left LOTC was significantly attenuated in the ASD group. We also observed significant group differences in the perspective effect in the medial prefrontal cortex (mPFC). Correlation analysis revealed that the perspective effect in the inferior parietal lobule (IPL) and cerebellum was associated with the gestural imitation ability in individuals with ASD. Our study suggests that atypical visual self-body recognition in individuals with ASD is associated with an altered perspective effect in the LOTC and mPFC, which are thought to be involved in the physical and core selves, respectively. Furthermore, the gestural imitation difficulty in individuals with ASD might be associated with the altered activation in the IPL and cerebellum, but not in the LOTC. These findings shed light on common and divergent neural mechanisms underlying atypical visual self-body awareness and gestural interaction in ASD. Own-body awareness and gestural skills are altered in autism spectrum disorder (ASD). The lateral occipito-temporal cortex (LOTC) is key for body perspective and identity. The perspective effects in the LOTC and medial prefrontal cortex are altered in ASD. Inferior parietal lobule and cerebellum activity underlie imitation deficits in ASD. Identity and perspective dysperception may alter the body-gesture interaction in ASD.
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影响因子：
1.8
作者：
Bressler, David W.;Fortenbaugh, Francesca C.;Robertson, Lynn C.;Silver, Michael A.
通讯作者：
Silver, Michael A.
DOI：
10.1093/cercor/bhn181
发表时间：
2009-06
期刊：
Cerebral cortex (New York, N.Y. : 1991)
影响因子：
--
作者：
Gazzola V;Keysers C
通讯作者：
Keysers C
影响因子：
10.6
作者：
Constantino, JN;Todd, RD
通讯作者：
Todd, RD
影响因子：
1.7
作者：
Chan, AWY;Peelen, MV;Downing, PE
通讯作者：
Downing, PE
影响因子：
2
作者：
Downing, Paul E.;Peelen, Marius V.;Tew, Bryn D.
通讯作者：
Tew, Bryn D.