Chronic Stability of Local Field Potentials Using Amorphous Silicon Carbide Microelectrode Arrays Implanted in the Rat Motor Cortex.
Chronic Stability of Local Field Potentials Using Amorphous Silicon Carbide Microelectrode Arrays Implanted in the Rat Motor Cortex.
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DOI：
10.3390/mi14030680
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发表时间：
2023-03-19
期刊：
影响因子：
3.4
通讯作者：
Hernandez-Reynoso AG
中科院分区：
文献类型：
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作者：
Jeakle EN;Abbott JR;Usoro JO;Wu Y;Haghighi P;Radhakrishna R;Sturgill BS;Nakajima S;Thai TTD;Pancrazio JJ;Cogan SF;Hernandez-Reynoso AG
可植入微电极阵列（MEA）能够记录皮层神经元的电活动，从而允许开发脑机接口。然而，MEA在慢性条件下显示出降低的记录能力，这促使开发可以改善长期性能的新型MEA。将常规平面硅基器件和超薄无定形碳化硅（a-SiC）MEA植入雌性Sprague-Dawley大鼠的运动皮质中，并在植入后16周每周进行麻醉记录。在植入期间，比较了两种器械类型在1和500 Hz之间记录的频谱密度和频带功率。最初，a-SiC器件和标准MEA的带宽功率相当。然而，标准MEA在植入后16周内显示出频带功率和功率谱密度的一致下降，而a-SiC MEA显示出更稳定的性能。从植入后第6周到研究结束第16周，标准和a-SiC MEA之间的带功率和谱密度差异具有统计学显著性。这些结果支持使用超薄a-SiC MEA来开发慢性、可靠的脑机接口。
Implantable microelectrode arrays (MEAs) enable the recording of electrical activity of cortical neurons, allowing the development of brain-machine interfaces. However, MEAs show reduced recording capabilities under chronic conditions, prompting the development of novel MEAs that can improve long-term performance. Conventional planar, silicon-based devices and ultra-thin amorphous silicon carbide (a-SiC) MEAs were implanted in the motor cortex of female Sprague–Dawley rats, and weekly anesthetized recordings were made for 16 weeks after implantation. The spectral density and bandpower between 1 and 500 Hz of recordings were compared over the implantation period for both device types. Initially, the bandpower of the a-SiC devices and standard MEAs was comparable. However, the standard MEAs showed a consistent decline in both bandpower and power spectral density throughout the 16 weeks post-implantation, whereas the a-SiC MEAs showed substantially more stable performance. These differences in bandpower and spectral density between standard and a-SiC MEAs were statistically significant from week 6 post-implantation until the end of the study at 16 weeks. These results support the use of ultra-thin a-SiC MEAs to develop chronic, reliable brain-machine interfaces.
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影响因子：
4
作者：
Barrese JC;Aceros J;Donoghue JP
通讯作者：
Donoghue JP
影响因子：
24.8
作者：
Andersen RA;Hwang EJ;Mulliken GH
通讯作者：
Mulliken GH
细胞外田地和电流的起源-EEG，ECOG，LFP和尖峰。
DOI：
10.1038/nrn3241
发表时间：
2012-05-18
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Buzsáki G;Anastassiou CA;Koch C
通讯作者：
Koch C
影响因子：
4.9
作者：
Cogan, SF;Edell, DJ;Edell, R
通讯作者：
Edell, R
影响因子：
4
作者：
通讯作者：
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