Self-reported medication adherence and symptom experience in adults with HIV.
Self-reported medication adherence and symptom experience in adults with HIV.
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DOI：
10.1016/j.jana.2010.11.004
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发表时间：
2011-07
影响因子：
2
通讯作者：
Lee, Kathryn A.
中科院分区：
文献类型：
--
作者：
Gay, Caryl;Portillo, Carmen J.;Kelly, Ryan;Coggins, Traci;Davis, Harvey;Aouizerat, Bradley E.;Pullinger, Clive R.;Lee, Kathryn A.
症状负担已被确定为药物依从性的预测因子，但对哪些症状最强烈地牵连到药物依从性知之甚少。本研究调查了302名成年艾滋病毒感染者自我报告的依从性与人口统计学、临床和症状特征的关系。只有12%的人在3天的评估中报告了药物缺失，但75%的人在前一个月至少给出了一个药物缺失的原因。依从性差与较高的病毒载量和较大的症状负担相关。睡眠障碍和注意力难以集中与依从性差密切相关。鉴于“遗忘”是错过药物的最常见原因，近三分之一的人报告在服药时间内睡觉，未来的研究应该检查睡眠障碍对依从性的影响。有效管理常见症状，如睡眠障碍，疲劳和药物的胃肠道副作用，可能会导致更好的依从性，以及改善临床结果和生活质量。
Symptom burden has been identified as a predictor of medication adherence, but little is known about which symptoms are most strongly implicated. This study examines self-reported adherence in relation to demographic, clinical, and symptom characteristics among 302 adults living with HIV. Only 12% reported missing medication during the 3-day assessment, but 75% gave at least one reason for missing medication in the prior month. Poor adherence was associated with higher viral load and greater symptom burden. Trouble sleeping and difficulty concentrating were strongly associated with poor adherence. Given that “forgetting” was the most common reason for missing medication and nearly one third reported sleeping through dose time, future research should examine the influence of sleep disturbance on adherence. Effective management of common symptoms, such as sleep disturbance, fatigue, and gastrointestinal side effects of medications may result in better adherence, as well as improved clinical outcomes and quality of life.
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影响因子：
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作者：
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影响因子：
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作者：
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