A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition.
A U-shaped relationship between plasma folate and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition.
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DOI：
10.1016/j.ejca.2011.02.007
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发表时间：
2011-08
影响因子：
8.4
通讯作者：
Vineis, Paolo
中科院分区：
文献类型：
--
作者：
Chuang, Shu-Chun;Stolzenberg-Solomon, Rachael;Ueland, Per Magne;Vollset, Stein Emil;Midttun, Oivind;Olsen, Anja;Tjonneland, Anne;Overvad, Kim;Boutron-Ruault, Marie-Christine;Morois, Sophie;Clavel-Chapelon, Francoise;Teucher, Birgit;Kaaks, Rudolf;Weikert, Cornelia;Boeing, Heiner;Trichopoulou, Antonia;Benetou, Vassiliki;Naska, Androniki;Jenab, Mazda;Slimani, Nadia;Romieu, Isabelle;Michaud, Dominique S.;Palli, Domenico;Sieri, Sabina;Panico, Salvatore;Sacerdote, Carlotta;Tumino, Rosario;Skeie, Guri;Duell, Eric J.;Rodriguez, Laudina;Molina-Montes, Esther;Maria Huerta, Jose;Larranaga, Nerea;Barricarte Gurrea, Aurelio;Johansen, Dorthe;Manjer, Jonas;Ye, Weimin;Sund, Malin;Peeters, Petra H. M.;Jeurnink, Suzanne;Wareham, Nicholas;Khaw, Kay-Tee;Crowe, Francesca;Riboli, Elio;Bueno-de-Mesquita, Bas;Vineis, Paolo
叶酸摄入量与胰腺癌呈负相关；然而，血浆测量的结果并不一致。本研究的目的是在欧洲癌症与营养前瞻性调查 (EPIC) 中探讨血浆总同型半胱氨酸、蛋氨酸、叶酸、钴胺素、5′-磷酸吡哆醛、核黄素和黄素单核苷酸与胰腺癌风险之间的关联。我们在 EPIC 队列中进行了一项巢式病例对照研究，该研究平均随访时间为 9.6 年（1992 年至 2006 年），使用了 463 例胰腺癌病例。对照按中心、性别、年龄 (+/-1y)、采血日期 (+/-1y) 和时间 (+/-3h) 以及禁食状态与每个病例相匹配。使用条件逻辑回归来计算比值比 (OR) 和 95% 置信区间 (CI)，并调整教育程度、吸烟状况、血浆可替宁浓度、饮酒情况、体重指数和糖尿病状况。我们观察到血浆叶酸与胰腺癌风险之间存在 U 形关联。血浆叶酸≤5、5-10、10-15（参考）、15-20 和 >20 nmol/L 的 OR 分别为 1.6（95% CI=0.7-3.5）、1.4（0.9-2.1）、1.0（参考）、0.8（0.5-1.2）和分别为 1.3 (0.9–2.0)。蛋氨酸与男性风险增加相关（每五分位增量：OR=1.2 95% CI=1.0–1.4），但与女性无关（OR=0.9，95% CI=0.8–1.1；异质性 p<0.01）。我们的结果表明，男性和女性的血浆叶酸与胰腺癌风险之间存在 U 形关联。我们观察到的蛋氨酸与胰腺癌之间的正相关可能具有性别依赖性，并且可能因随访时间而异。然而，观察到的关联背后的机制值得进一步研究。
Folate intake has shown an inverse association with pancreatic cancer; nevertheless, results from plasma measurements were inconsistent. The aim of this study is to examine the association between plasma total homocysteine, methionine, folate, cobalamin, pyridoxal 5′-phosphate, riboflavin, and flavin mononucleotide and pancreatic cancer risk in the European Prospective Investigation into Cancer and Nutrition (EPIC). We conducted a nested case-control study in the EPIC cohort, which has an average of 9.6 years of follow-up (1992–2006), using 463 incident pancreatic cancer cases. Controls were matched to each case by center, sex, age (+/−1y), date (+/−1y) and time (+/−3h) at blood collection, and fasting status. Conditional logistic regression was used to calculate the odds ratios (OR) and 95% confidence intervals (CI), adjusting for education, smoking status, plasma cotinine concentration, alcohol drinking, body mass index and diabetes status. We observed a U-shaped association between plasma folate and pancreatic cancer risk The ORs for plasma folate ≤5, 5–10, 10–15 (reference), 15–20, and >20 nmol/L were 1.6 (95% CI=0.7–3.5), 1.4 (0.9–2.1), 1.0 (reference), 0.8 (0.5–1.2), and 1.3 (0.9–2.0), respectively. Methionine was associated with an increased risk in men (per quintile increment: OR=1.2 95% CI=1.0–1.4) but not in women (OR=0.9, 95% CI=0.8–1.1; p for heterogeneity<0.01). Our results suggest a U-shaped association between plasma folate and pancreatic cancer risk in both men and women. The positive association that we observed between methionine and pancreatic cancer may be sex dependent and may differ by time of follow-up. However, the mechanisms behind the observed associations warrant further investigation.
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影响因子：
9.3
作者：
Windelberg, A;Årseth, O;Ueland, PM
通讯作者：
Ueland, PM
影响因子：
3.6
作者：
Drogan, D;Klipstein-Grobusch, K;Dierkes, J
通讯作者：
Dierkes, J
影响因子：
4.7
作者：
Skeie, G.;Braaten, T.;Slimani, N.
通讯作者：
Slimani, N.
影响因子：
6.4
作者：
Vrieling, Alina;Bueno-de-Mesquita, H. Bas;Riboli, Elio
通讯作者：
Riboli, Elio
影响因子：
29.4
作者：
Larsson, Susanna G.;Giovannucci, Edward;Wolk, Alicja
通讯作者：
Wolk, Alicja