The Underlying Mechanisms in the Association Between Traumatic Brain Injury in Childhood and Conduct Disorder Symptoms in Late Adolescence.
The Underlying Mechanisms in the Association Between Traumatic Brain Injury in Childhood and Conduct Disorder Symptoms in Late Adolescence.
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DOI：
10.1007/s10802-022-01015-y
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发表时间：
2023-05
影响因子：
2.5
通讯作者：
Barker, Edward D.
中科院分区：
文献类型：
--
作者：
Khalaf, Hanan K. S.;Martin, Alex F.;De Brito, Stephane A.;Barker, Edward D.
关键词：
本研究探讨了i）儿童期创伤性脑损伤（TBI）与青少年期行为障碍症状之间的直接关联，ii）这种影响是否由冲动和/或冷酷无情的非情感特质（CU特质）介导，iii）这些间接影响是否由儿童期家庭逆境和青少年物质使用调节。利用雅芳父母和儿童纵向研究（ALSPAC）的数据，确定了头部损伤信息长达12年（4.5年，5.4年，6.5年，8.6年，11.7年）的参与者，并将其分为TBI（n = 409），骨科损伤（n = 1469）或非损伤组（n = 5685）。心理社会因素，如冲动在13年，CU性状在13年，童年家庭逆境（出生至4岁）和物质使用在14年进行了整理，为适度的中介分析。在16岁时评估行为障碍症状。TBI和行为障碍症状呈正相关，这种关联是由冲动介导的，但不是CU特征。间接影响的幅度较高的个人与较高水平的童年家庭逆境。未发现青少年物质使用对TBI和行为障碍症状之间的间接影响有调节作用。这些结果是针对TBI个体的，而不是在骨科损伤和无损伤报告的参与者中。针对冲动和早期家庭逆境可能会减轻儿童TBI后行为障碍症状的风险。这些发现对临床和社区环境中的神经康复和预防措施具有重要意义。 在线版本包含补充材料，可通过10.1007/s10802-022-01015-y获得。
The present study examined i) the direct association between traumatic brain injury (TBI) in childhood and conduct disorder symptoms in adolescence, ii) whether this effect is mediated by impulsivity and/or callous unemotional traits (CU traits), and iii) whether these indirect effects are moderated by childhood family adversity and adolescent substance use. Utilising data from the Avon Longitudinal Study of Parents and Children (ALSPAC), participants with head injury information up to 12 years (4.5 years, 5.4 years, 6.5 years, 8.6 years, 11.7 years) were identified and categorised into a TBI (n = 409), orthopaedic injury (n = 1469) or non-injury group (n = 5685). Psychosocial factors such as impulsivity at 13 years, CU traits at 13 years, childhood family adversity (between birth to 4 years) and substance use at 14 years were collated for moderated mediation analyses. Conduct disorder symptoms were assessed at 16 years of age. TBI and conduct disorder symptoms were positively associated, and this association was mediated by impulsivity but not CU traits. The indirect effects were higher in magnitude for individuals with higher levels of childhood family adversity. Adolescent substance use was not found to moderate the indirect effects between TBI and conduct disorder symptoms. These results were specific to TBI individuals, and not in participants with orthopaedic injury and no reported injuries. Targeting impulsivity and early family adversity may alleviate the risk of conduct disorder symptoms following TBI in childhood. These findings have important implications for informing neuro-rehabilitative and preventative measures in clinical and community settings. The online version contains supplementary material available at 10.1007/s10802-022-01015-y.
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影响因子：
3.6
作者：
Brame, R;Piquero, AR
通讯作者：
Piquero, AR
DOI：
10.5812/ijhrba.20428
发表时间：
2014-06
影响因子：
--
作者：
Bakhshani NM
通讯作者：
Bakhshani NM
影响因子：
4.4
作者：
Dawe, S;Gullo, MJ;Loxton, NJ
通讯作者：
Loxton, NJ
影响因子：
2.6
作者：
Boes, Aaron D.;Grafft, Amanda Hornaday;Anderson, Steven W.
通讯作者：
Anderson, Steven W.
影响因子：
--
作者：
Green, Jennifer Greif;McLaughlin, Katie A.;Berglund, Patricia A.;Gruber, Michael J.;Sampson, Nancy A.;Zaslavsky, Alan M.;Kessler, Ronald C.
通讯作者：
Kessler, Ronald C.