Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders.
Childhood adversities and adult psychiatric disorders in the national comorbidity survey replication I: associations with first onset of DSM-IV disorders.
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DOI：
10.1001/archgenpsychiatry.2009.186
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发表时间：
2010-02
影响因子：
--
通讯作者：
Kessler, Ronald C.
中科院分区：
文献类型：
--
作者：
Green, Jennifer Greif;McLaughlin, Katie A.;Berglund, Patricia A.;Gruber, Michael J.;Sampson, Nancy A.;Zaslavsky, Alan M.;Kessler, Ronald C.
尽管流行病学调查一致记录了童年逆境（CAs）与成人精神障碍的显著关联，但这些研究通常只检查了一项CA。由于ca是高度集群的，这种方法会导致高估单个ca的重要性。多元CA研究一直基于不够复杂的模型。在国家合并症调查复制（NCS-R）中，使用复杂的多变量模型检查12例回顾性报道的CAs与首次发病的DSM-IV障碍的联合关联。横断面社区调查与回顾性报告的ca和终身DSM-IV障碍。美国家庭人口中5692名成年人的全国代表性样本。用世卫组织综合国际诊断访谈（CIDI）评估20种DSM-IV焦虑、情绪、破坏性行为和物质障碍的终生患病率。所研究的ca高度普遍且相互关联。适应不良家庭功能（MFF）集群（父母精神疾病、物质障碍和犯罪行为；家庭暴力；身体虐待；性虐待；忽视）中的ca与障碍发作的相关性最强。最佳拟合模型包括每种CA类型的术语、MFF CA的数量和其他CA的数量。多个MFF ca与疾病发作有显著的亚加性关联。对于具有特定疾病的特定CAs，几乎没有发现特异性。相关性随生命历程阶段和既往生活障碍数量的增加而下降，但随回忆时间的延长而增加。模拟表明，ca与44.6%的儿童期发病障碍和25.9-32.0%的晚发病障碍有关。联想随着回忆时间的延长而增加，这一事实增加了回忆偏差夸大估计的可能性。然而，即使考虑到这一点，结果表明，在整个生命过程中，ca与许多类型的主要是原发性精神障碍的发病有着强大的、往往是亚加性的关联。
Although significant associations of childhood adversities (CAs) with adult mental disorders have been documented consistently in epidemiological surveys, these studies generally have examined only one CA per study. As CAs are highly clustered, this approach results in over-estimating the importance of individual CAs. Multivariate CA studies have been based on insufficiently complex models. To examine the joint associations of 12 retrospectively reported CAs with first onset of DSM-IV disorders in the National Comorbidity Survey Replication (NCS-R) using substantively complex multivariate models. Cross-sectional community survey with retrospective reports of CAs and lifetime DSM-IV disorders. Nationally representative sample of 5,692 adults in the US household population. None Lifetime prevalence of 20 DSM-IV anxiety, mood, disruptive behavior, and substance disorders assessed with the WHO Composite International Diagnostic Interview (CIDI). The CAs studied were highly prevalent and inter-correlated. CAs in a maladaptive family functioning (MFF) cluster (parental mental illness, substance disorder, and criminal behavior; family violence; physical abuse; sexual abuse; neglect) were the strongest correlates of disorder onset. The best-fitting model included terms for each type of CA, number of MFF CAs, and number of other CAs. Multiple MFF CAs had significant sub-additive associations with disorder onset. Little specificity was found for particular CAs with particular disorders. Associations declined in magnitude with life course stage and number of prior lifetime disorders, but increased with length of recall period. Simulations suggest that CAs are associated with 44.6% of all childhood-onset disorders and 25.9-32.0% of later-onset disorders. The fact that associations increased with length of recall raises the possibility of recall bias inflating estimates. Even taking this into consideration, though, the results suggest that CAs have powerful and often sub-additive associations with onset of many types of largely primary mental disorders throughout the life course.
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影响因子：
6.9
作者：
Hazel, N. A.;Hammen, C.;Najman, J.
通讯作者：
Najman, J.
影响因子：
4.8
作者：
Arata, Catalina M.;Langhinrichsen-Rohling, Jennifer;O'Brien, Natalie
通讯作者：
O'Brien, Natalie
影响因子：
3.6
作者：
Espejo, Emmanuel P.;Hammen, Constance L.;Bor, William
通讯作者：
Bor, William
影响因子：
--
作者：
Dong, MX;Anda, RF;Giles, WH
通讯作者：
Giles, WH
DOI：
10.1111/j.1469-7610.2007.01868.x
发表时间：
2008-06-01
影响因子：
7.6
作者：
Borges, Guilherme;Benjet, Corina;Nock, Matthew K.
通讯作者：
Nock, Matthew K.