Molecular epidemiological analysis of dengue fever in Bolivia from 1998 to 2008.

Molecular epidemiological analysis of dengue fever in Bolivia from 1998 to 2008.
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DOI:
10.1089/vbz.2008.0187
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发表时间:
2009-06
期刊:
Vector borne and zoonotic diseases (Larchmont, N.Y.)
影响因子:
--
通讯作者:
de Lamballerie X
de Lamballerie X
中科院分区:
其他
文献类型:
--
作者:
Roca Y;Baronti C;Revollo RJ;Cook S;Loayza R;Ninove L;Fernandez RT;Flores JV;Herve JP;de Lamballerie X

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登革热于 1931 年在玻利维亚首次被发现。然而,迄今为止,有关玻利维亚登革热病毒株的遗传特征和流行病学的信息非常有限。在这里,我们对 1998 年至 2008 年 64 个玻利维亚分离株的全长包膜基因进行了遗传表征,并研究了它们的起源和进化,以确定菌株是否同时或交替传播,以及在研究期间是否发生了不同病毒变体的多次引入。我们确定,在过去十年中,密切相关的病毒连续几年(DENV-1、DENV-2和DENV-3分别为5年、6年和6年)传播,并且观察到两种甚至三种血清型的共同传播。在 DENV-1(2007 年爆发)和 DENV-2(2001 年爆发)的病例中发现了新变种(与之前事件中发现的变种不同)的出现。在所有情况下,病毒很可能源自邻国。
Dengue fever was first recognized in Bolivia in 1931. However, very limited information was available to date regarding the genetic characterization and epidemiology of Bolivian dengue virus strains. Here, we performed genetic characterization of the full-length envelope gene of 64 Bolivian isolates from 1998 to 2008 and investigated their origin and evolution to determine whether strains circulated simultaneously or alternatively, and whether or not multiple introductions of distinct viral variants had occurred during the period studied. We determined that, during the last decade, closely related viruses circulated during several consecutive years (5, 6, and 6 years for DENV-1, DENV-2, and DENV-3, respectively) and the co-circulation of two or even three serotypes was observed. Emergence of new variants (distinct from those identified during the previous episodes) was identified in the case of DENV-1 (2007 outbreak) and DENV-2 (2001 outbreak). In all cases, it is likely that the viruses originated from neighboring countries.
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