A trifluoroacetic acid-labile sulfonate protecting group and its use in the synthesis of a near-IR fluorophore.
A trifluoroacetic acid-labile sulfonate protecting group and its use in the synthesis of a near-IR fluorophore.
复制标题
DOI：
10.1021/jo302065u
复制
发表时间：
2013-01-18
期刊：
影响因子：
--
通讯作者：
Miller SC
中科院分区：
文献类型：
--
作者：
Pauff SM;Miller SC
Sulfonated molecules exhibit high water solubility, a property which is valuable for many biological applications but often complicates their synthesis and purification. Here we report a sulfonate protecting group that is resistant to nucleophilic attack but readily removed with trifluoroacetic acid (TFA). The use of this protecting group improved the synthesis of a sulfonated near-IR fluorophore and the mild deprotection conditions allowed isolation of the product without requiring chromatography.
登录
查看更多内容
影响因子：
3.6
作者：
Ali, Ahmed M.;Hill, Bryan;Taylor, Scott D.
通讯作者：
Taylor, Scott D.
影响因子：
3.6
作者：
Miller, Stephen C.
通讯作者：
Miller, Stephen C.
影响因子：
15
作者：
Simpson, LS;Widlanski, TS
通讯作者：
Widlanski, TS
影响因子：
3.2
作者：
Panchuk-Voloshina, N;Haugland, RP;Haugland, RP
通讯作者：
Haugland, RP
影响因子：
5.2
作者：
Song, JJ;Tan, ZL;Senanayake, CH
通讯作者：
Senanayake, CH