Indoor air pollution exposure is associated with greater morbidity in cystic fibrosis.
Indoor air pollution exposure is associated with greater morbidity in cystic fibrosis.
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DOI：
10.1016/j.jcf.2021.08.015
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发表时间：
2022-03
期刊：
影响因子：
--
通讯作者：
Merlo CA
中科院分区：
文献类型：
--
作者：
Carson SW;Psoter K;Koehler K;Siklosi KR;Montemayor K;Toporek A;West NE;Lechtzin N;Hansel NN;Collaco JM;Merlo CA
暴露于较高水平的室外空气污染与囊性纤维化患者的发病率增加有关。关于室内空气污染对囊性纤维化患者的潜在不利影响的信息有限。2000年至2013年期间参加双胞胎和兄弟姐妹研究的囊性纤维化患者，自我报告暴露于四种已知的室内空气污染源（二手烟，强制热空气，木炉子和壁炉）。对肺功能的变化、住院率和肺恶化率进行了4年以上的随访，以比较接触者和未接触者的结果。在1432名有二手烟暴露数据的参与者中，362人（25.3%）暴露于二手烟。在765名有强迫热空气暴露数据的个人中，有491人（64.2%）暴露过。在1247名有柴炉暴露数据的参与者和830名有壁炉暴露数据的参与者中，分别有182人（14.6%）和373人（44.9%）暴露于空气中。在纵向分析中，与未暴露于二手烟或强迫热空气中的儿童相比，暴露于二手烟或强迫热空气中的儿童的FEV1%预测年下降率分别为0.60% （P=0.002）或0.46% （P=0.048）。与未接触二手烟的成年人相比，接触二手烟的成年人每年住院的风险增加42% （P=0.045）。我们基于问卷调查的数据表明，暴露于室内空气污染源会增加儿童和成人囊性纤维化人群的发病率。未来需要进行室内空气质量定量评估的研究。
Exposure to higher levels of outdoor air pollution is associated with increased morbidity in individuals with cystic fibrosis. Limited information exist regarding the potential adverse effects of indoor air pollution on those with cystic fibrosis. Individuals with cystic fibrosis who were enrolled in the Twin and Sibling Study from 2000–2013, self-reported exposure to four known sources of indoor air pollution (secondhand smoke, forced hot air, wood stove and fireplace). Change in lung function, rates of hospitalizations and pulmonary exacerbations were followed over 4 years to compare outcomes in those who were exposed to those who were not exposed. Of 1432 participants with data on secondhand smoke exposure, 362 (25.3%) were exposed. Of 765 individuals with data on forced hot air exposure, 491 (64.2%) were exposed. Of 1247 participants with data on wood stove exposure and 830 with data on fireplace exposure, 182 (14.6%) and 373 (44.9%) were exposed, respectively. In longitudinal analysis, pediatric individuals either exposed to secondhand smoke or to forced hot air had a 0.60% predicted/year decrease in FEV1% predicted (P=0.002) or a 0.46% predicted/year decrease in FEV1% predicted (P=0.048), respectively compared to individuals who were not exposed. Adults exposed to secondhand smoke had a 42% increased yearly risk of hospitalization compared to those who were not exposed (P=0.045). Our questionnaire-based data suggest that exposure to sources of indoor air pollution increase morbidity in both the pediatric and adult cystic fibrosis populations. Future studies with quantitative indoor air quality assessments are needed.
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3-95 岁年龄范围的多种族肺活量测定参考值：2012 年全球肺功能方程。
DOI：
10.1183/09031936.00080312
发表时间：
2012-12
期刊：
The European respiratory journal
影响因子：
--
作者：
Quanjer PH;Stanojevic S;Cole TJ;Baur X;Hall GL;Culver BH;Enright PL;Hankinson JL;Ip MS;Zheng J;Stocks J;ERS Global Lung Function Initiative
通讯作者：
ERS Global Lung Function Initiative
影响因子：
3.7
作者：
Lechtzin, N;John, M;Boyle, MP
通讯作者：
Boyle, MP
影响因子：
5
作者：
Corey, M;Farewell, V
通讯作者：
Farewell, V
影响因子：
5.2
作者：
Konstan, Michael W.;Wagener, Jeffrey S.;Morgan, Wayne J.
通讯作者：
Morgan, Wayne J.
影响因子：
158.5
作者：
KEREM, E;REISMAN, J;LEVISON, H
通讯作者：
LEVISON, H