Glial restricted precursor cells in central nervous system disorders: Current applications and future perspectives.
Glial restricted precursor cells in central nervous system disorders: Current applications and future perspectives.
复制标题
中枢神经系统疾病中的神经胶质限制前体细胞：当前的应用和未来观点。
作者：
Martins-Macedo J;Lepore AC;Domingues HS;Salgado AJ;Gomes ED;Pinto L
神经胶质细胞和神经元之间的串扰是维持中枢神经系统(CNS)正常功能的一个特殊特征。越来越多的证据表明，神经胶质前体细胞在成体神经发生、细胞池重建、神经再生和轴突(再)髓鞘形成中的重要性。已经描述了几种类型的神经胶质前体细胞，以及它们从某些创伤或病理中恢复中枢神经系统的潜力。在这些前体细胞中，胶质限制前体细胞(GRPs)被认为是最早的神经胶质前体细胞，对I/II型星形胶质细胞和少突胶质细胞都具有三能性。GRPs已经在动物模型中从胚胎和胚胎干细胞中获得，并保持了自我更新的能力。尽管对这些祖细胞的分离、鉴定和功能的了解相对有限，但GRP在神经退行性疾病和神经精神障碍以及创伤中的移植治疗和中枢神经系统功能的重建/修复方面是很有前途的候选细胞。在此，我们综述了GRP的定义、分离、特征及其在不同神经系统条件下作为基于细胞的治疗的潜力。我们简要讨论了在中枢神经系统再生医学中使用GRPS的意义以及它们在临床环境中的可能应用。GRPs是存在于中枢神经系统的前体细胞，其分化潜能仅限于神经胶质细胞系。这些细胞已经被用于治疗无数的神经退行性疾病和创伤病理，并伴随着有希望的结果，在此综述。
The crosstalk between glial cells and neurons represents an exceptional feature for maintaining the normal function of the central nervous system (CNS). Increasing evidence has revealed the importance of glial progenitor cells in adult neurogenesis, reestablishment of cellular pools, neuroregeneration, and axonal (re)myelination. Several types of glial progenitors have been described, as well as their potentialities for recovering the CNS from certain traumas or pathologies. Among these precursors, glial-restricted precursor cells (GRPs) are considered the earliest glial progenitors and exhibit tripotency for both Type I/II astrocytes and oligodendrocytes. GRPs have been derived from embryos and embryonic stem cells in animal models and have maintained their capacity for self-renewal. Despite the relatively limited knowledge regarding the isolation, characterization, and function of these progenitors, GRPs are promising candidates for transplantation therapy and reestablishment/repair of CNS functions in neurodegenerative and neuropsychiatric disorders, as well as in traumatic injuries. Herein, we review the definition, isolation, characterization and potentialities of GRPs as cell-based therapies in different neurological conditions. We briefly discuss the implications of using GRPs in CNS regenerative medicine and their possible application in a clinical setting. GRPs are progenitors present in the CNS with differentiation potential restricted to the glial lineage. These cells have been employed in the treatment of a myriad of neurodegenerative and traumatic pathologies, accompanied by promising results, herein reviewed.
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影响因子：
6.2
作者：
Azevedo, Maria M.;Domingues, Helena S.;Relvas, Joao B.
通讯作者：
Relvas, Joao B.
影响因子：
16.6
作者：
Batiuk, Mykhailo Y.;Martirosyan, Araks;Holt, Matthew G.
通讯作者：
Holt, Matthew G.
影响因子：
6.2
作者：
Blakemore, WF;Chari, DM;Crang, AJ
通讯作者：
Crang, AJ
DOI：
10.1073/pnas.90.1.50
发表时间：
1993-01-01
影响因子：
11.1
作者：
DELOSMONTEROS, AE;ZHANG, MS;DEVELLIS, J
通讯作者：
DEVELLIS, J
影响因子：
3
作者：
Boucanova, Filipa;Maia, Andre Filipe;Domingues, Helena Sofia
通讯作者：
Domingues, Helena Sofia