Impact of Serum Lipid on Breast Cancer Recurrence.
Impact of Serum Lipid on Breast Cancer Recurrence.
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DOI：
10.3390/jcm9092846
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发表时间：
2020-09-02
影响因子：
3.9
通讯作者：
Lee SK
中科院分区：
文献类型：
--
作者：
Jung SM;Kang D;Guallar E;Yu J;Lee JE;Kim SW;Nam SJ;Cho J;Lee SK
血脂水平与乳腺癌预后的关系存在争议。本研究旨在探讨血脂水平对乳腺癌复发的影响。我们分析了4190例可手术乳腺癌患者的基线血脂谱;总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A-1和载脂蛋白B。无复发生存期定义为从根治性手术日期到检测到任何复发所经过的时间，复发包括局部区域复发、远处转移或局部和远处转移。使用Cox比例风险分析估计研究结局的风险比和95%置信区间（CI），比较每个脂质参数的三个最低四分位数与最高四分位数，调整乳腺癌诊断时的年龄、体重指数（BMI）和病理分期、雌激素受体（ER）、孕激素受体（PR）、合并症（高血压、糖尿病或血管事件）。血脂异常患者（高坏胆固醇和低好胆固醇水平）的预后因素更差（即，阴性激素受体状态，阳性人表皮生长因子受体2（HER 2）表达，较高的细胞核级别）。在调整这些不良预后因素后，血脂异常患者乳腺癌复发的预后良好。我们的研究表明，基线高血脂水平可能是乳腺癌的一个良好的预后因素。这项研究表明，心血管疾病风险的脂质谱的理想变化并不总是有益于乳腺癌患者。然而，由于适当控制血脂水平对心血管疾病有好处，这些发现需要仔细解释。
The association between serum lipid level and prognosis of breast cancer is controversial. The purpose of this study was to evaluate the impact of serum lipid level in breast cancer recurrence. We analyzed a total of 4190 patients with operable breast cancer who had baseline serum lipid profiles; total cholesterol (TC), triglycerides (TG), low density lipoprotein-cholesterol (LDL-C), high density lipoprotein-cholesterol (HDL-C), apolipoprotein A-1, and apolipoprotein B. Recurrence-free survival is defined as the elapsed time from the date of curative surgery to the detection of any recurrence, and recurrence includes locoregional recurrence, distant metastasis, or both local and distant metastasis. Cox-proportional hazard analysis was used to estimate hazard ratios with 95% confidence intervals (CI) for study outcomes comparing the three lowest quartiles of each lipid parameter to the highest quartile adjusting for age, body mass index (BMI), and pathologic stage, estrogen receptor (ER), progesterone receptor (PR), comorbidities (hypertension, diabetes, or vascular event) at time of breast cancer diagnosis. Patients with dyslipidemia (high bad cholesterol and low good cholesterol level) had worse prognostic factors (i.e., negative hormone receptor status, positive human epidermal growth factor receptor 2 (HER2) expression, higher nuclear grade). After adjusting for these poor prognostic factors, the patients with dyslipidemia showed good prognosis for breast cancer recurrence. Our study showed that baseline high lipid level could be a good prognostic factor of breast cancer. This study indicates that desirable changes in lipid profile for cardiovascular disease risk are not always beneficial for patients with breast cancer. However, as proper control of lipid level has advantages for cardiovascular disease, these findings require careful interpretation.
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影响因子：
37.8
作者：
Goff, DC;Bertoni, AG;Psaty, BM
通讯作者：
Psaty, BM
DOI：
10.1590/s1807-59322008000400003
发表时间：
2008-08
期刊：
Clinics (Sao Paulo, Brazil)
影响因子：
--
作者：
da Luz PL;Favarato D;Faria-Neto JR Jr;Lemos P;Chagas AC
通讯作者：
Chagas AC
DOI：
10.1158/1055-9965.epi-10-1041
发表时间：
2011-05
期刊：
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology
影响因子：
--
作者：
Caan BJ;Natarajan L;Parker B;Gold EB;Thomson C;Newman V;Rock CL;Pu M;Al-Delaimy W;Pierce JP
通讯作者：
Pierce JP
DOI：
10.1093/annonc/mdu042
发表时间：
2014-10
期刊：
Annals of oncology : official journal of the European Society for Medical Oncology
影响因子：
--
作者：
Chan DSM;Vieira AR;Aune D;Bandera EV;Greenwood DC;McTiernan A;Navarro Rosenblatt D;Thune I;Vieira R;Norat T
通讯作者：
Norat T
影响因子：
3.8
作者：
Kwan, Marilyn L.;Habel, Laurel A.;Caan, Bette
通讯作者：
Caan, Bette