Ultraviolet radiation intensity predicts the relative distribution of dermatomyositis and anti-Mi-2 autoantibodies in women.
Ultraviolet radiation intensity predicts the relative distribution of dermatomyositis and anti-Mi-2 autoantibodies in women.
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DOI：
10.1002/art.24702
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发表时间：
2009-08
影响因子：
--
通讯作者：
Miller, Frederick W.
中科院分区：
文献类型：
--
作者：
Love, Lori A.;Weinberg, Clarice R.;McConnaughey, D. Robert;Oddis, Chester V.;Medsger, Thomas A., Jr.;Reveille, John D.;Arnett, Frank C.;Targoff, Ira N.;Miller, Frederick W.
由于研究表明紫外线辐射(UVR)调节肌炎表型和Mi-2自身抗原的表达，我们进行了一项回顾性调查，以确定UVR是否可能影响皮肌炎和抗Mi-2自身抗体在美国的相对患病率。我们评估了380名来自美国转诊中心的肌炎患者发病时居住状态下的表面紫外线强度与皮肌炎和肌炎自身抗体相对患病率的关系。肌炎自身抗体的检测采用有效的免疫沉淀试验。地表紫外线强度是根据美国国家气象局收集的紫外线指数数据估计的。紫外线强度与皮肌炎患者的相对比例(优势比[OR]2.3，95%可信区间[CI]0.9~5.8)和表达抗Mi-2自身抗体的患者比例(OR 6.0，CI 1.1~34.1)相关。对这些数据的模拟显示，这些关联仅限于女性(OR3.8，CI1.3-11.0和OR17.3，CI1.8-162.4)，并表明性别影响紫外线对自身免疫性疾病的影响。在男性中没有发现显著的相关性，UVR水平也与抗合成酶或抗信号识别颗粒自身抗体的存在无关。这项首次对美国肌炎表型分布和紫外线照射的研究表明，紫外线照射可能调节女性自身免疫性疾病的临床和免疫学表达。对产生这些效应的机制的进一步研究可能会对发病机制有深入的了解，并提出治疗或预防策略。
Because studies suggest that ultraviolet radiation (UVR) modulates myositis phenotype and Mi-2 autoantigen expression, we conducted a retrospective investigation to determine if UVR may influence the relative prevalence of dermatomyositis and anti-Mi-2 autoantibodies in the United States. We assessed the relationship between surface UVR intensity in the state of residence at the time of onset with the relative prevalence of dermatomyositis and myositis autoantibodies in 380 myositis patients from referral centers in the U.S. Myositis autoantibodies were detected by validated immunoprecipitation assays. Surface UVR intensity was estimated from UV index data collected by the U.S. National Weather Service. UVR intensity was associated with the relative proportion of patients with dermatomyositis (odds ratio [OR] 2.3, 95% confidence interval [CI] 0.9–5.8) and with the proportion of patients expressing anti-Mi-2 autoantibodies (OR 6.0, CI 1.1–34.1). Modeling of these data showed that these associations were confined to women (OR 3.8, CI 1.3–11.0 and OR 17.3, CI 1.8–162.4, respectively) and suggests that gender influences UVR effects on autoimmune disorders. Significant associations were not seen in men, nor were UVR levels related to the presence of anti-synthetase or anti-signal recognition particle autoantibodies. This first study of the distribution of myositis phenotypes and UVR exposure in the United States showed that UVR may modulate the clinical and immunologic expression of autoimmune disease in women. Further investigation of the mechanisms by which these effects are produced may give insights into pathogenesis and suggest therapeutic or preventative strategies.
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影响因子：
4.8
作者：
Yamaguchi, Yuji;Takahashi, Kaoruko;Hearing, Vincent J.
通讯作者：
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