A Mini-Review of Pediatric Anthropometrics as Predictors of Future Insulin Resistance.
A Mini-Review of Pediatric Anthropometrics as Predictors of Future Insulin Resistance.
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DOI：
10.3389/fendo.2022.826430
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发表时间：
2022
影响因子：
5.2
通讯作者：
Josefson JL
中科院分区：
文献类型：
--
作者：
DeLacey S;Josefson JL
儿童肥胖率上升的影响是深远的。儿童的代谢综合征正在增加，但对大多数儿童来说，过度肥胖的后果将在成年后显现。过多的早期脂肪积聚是未来胰岛素抵抗的风险因素。然而，某些类型的脂肪和脂肪分布模式比其他类型的脂肪与代谢风险更相关。因此，肥胖措施很重要。儿童肥胖和未来的胰岛素抵抗之间的联系最初是通过身体质量指数(BMI)建立起来的，但BMI并不是肥胖的完美衡量标准。评估其他人体测量学是值得的，因为它们可能更准确地捕捉代谢风险。虽然腰围与身高比等指标在成年时被确定为更好的筛查指标，但在儿科领域，这一发现并不那么有力。新出现的证据表明，替代人体测量学在确定最有可能出现胰岛素抵抗的年轻人方面可能略优于BMI，但这种优势的临床意义似乎有限。需要在纵向和不同的队列中进行更多的研究，以确定哪种儿科人体测量学最能预测成人胰岛素抵抗。我们回顾了替代的人体测量学作为未来胰岛素抵抗的预测指标，并确定了目前的知识差距和潜在的未来研究方向。
The impact of rising rates of childhood obesity is far reaching. Metabolic syndrome in children is increasing, yet for most children the consequences of excess adiposity will manifest in adulthood. Excess early fat accrual is a risk factor for future insulin resistance. However, certain types of fat and patterns of fat distribution are more relevant than others to metabolic risk. Therefore, adiposity measures are important. The link between childhood obesity and future insulin resistance was initially established with body mass index (BMI), but BMI is an in imperfect measure of adiposity. It is worthwhile to evaluate other anthropometrics as they may more accurately capture metabolic risk. While measures such as waist to height ratio are established as superior screening measures in adulthood - the findings are not as robust in pediatrics. Emerging evidence suggests that alternative anthropometrics may be slightly superior to BMI in identifying those youth most at risk of developing insulin resistance, but the clinical significance of that superiority appears limited. Increasing study is needed in longitudinal and varied cohorts to identify which pediatric anthropometric best predicts adult insulin resistance. We review alternative anthropometrics as predictors of future insulin resistance and identify current gaps in knowledge and potential future directions of inquiry.
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