Wearable and Implantable Electroceuticals for Therapeutic Electrostimulations.
Wearable and Implantable Electroceuticals for Therapeutic Electrostimulations.
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DOI：
10.1002/advs.202004023
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发表时间：
2021-04
期刊：
影响因子：
--
通讯作者：
Wang X
中科院分区：
文献类型：
--
作者：
Long Y;Li J;Yang F;Wang J;Wang X
用于治疗性电刺激的可穿戴和可植入电刺激设备(Wie)已成为现代医疗保健中不可或缺的医疗设备。除了功能之外，设备的小型化、顺应性、生物兼容性和/或生物降解性是WIE开发和临床翻译的主要工程目标。最近的创新主要集中在可穿戴/可植入电源、先进的可整合电极以及靶向器官和组织上的高效ES上。在此，综述了纳米发电机作为一种可穿戴/可植入的能量采集技术，适用于WIE的研究热点。然后，介绍和比较了用于舒适地附着和有效地将电信号传递到目标组织/器官的电极。讨论了ES的几个有前景的应用方向，包括心脏刺激、神经调节、皮肤再生、肌肉激活以及辅助其他治疗方式。综述了可穿戴和可植入电子设备(WIE)的最新创新，重点介绍了纳米发电机(NG)电源、先进的可整合电极以及对目标器官和组织的有效电刺激。基于NG的技术有望在不久的将来将并行的WIE转变为下一代精密电疗。
Wearable and implantable electroceuticals (WIEs) for therapeutic electrostimulation (ES) have become indispensable medical devices in modern healthcare. In addition to functionality, device miniaturization, conformability, biocompatibility, and/or biodegradability are the main engineering targets for the development and clinical translation of WIEs. Recent innovations are mainly focused on wearable/implantable power sources, advanced conformable electrodes, and efficient ES on targeted organs and tissues. Herein, nanogenerators as a hotspot wearable/implantable energy‐harvesting technique suitable for powering WIEs are reviewed. Then, electrodes for comfortable attachment and efficient delivery of electrical signals to targeted tissue/organ are introduced and compared. A few promising application directions of ES are discussed, including heart stimulation, nerve modulation, skin regeneration, muscle activation, and assistance to other therapeutic modalities. An overview of the most recent innovations in wearable and implantable electroceuticals (WIEs) with focus on nanogenerator (NG) power sources, advanced conformable electrodes, and efficient electrostimulation on targeted organs and tissues is presented. The NG‐based technology is foreseeable to transform the concurrent WIEs toward the next generation of precision electrotherapy in the near future.
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影响因子：
2.2
作者：
Bhadra, N;Kilgore, KL;Peckham, PH
通讯作者：
Peckham, PH
影响因子：
10.8
作者：
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通讯作者：
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DOI：
10.1002/jbm.10099
发表时间：
2002-06-15
期刊：
JOURNAL OF BIOMEDICAL MATERIALS RESEARCH
影响因子：
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作者：
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通讯作者：
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影响因子：
3.3
作者：
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通讯作者：
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DOI：
10.1111/ner.12397
发表时间：
2016-06
期刊：
Neuromodulation : journal of the International Neuromodulation Society
影响因子：
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作者：
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通讯作者：
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