Generation of Photopolymerized Microparticles Based on PEGDA Using Microfluidic Devices. Part 1. Initial Gelation Time and Mechanical Properties of the Material.
Generation of Photopolymerized Microparticles Based on PEGDA Using Microfluidic Devices. Part 1. Initial Gelation Time and Mechanical Properties of the Material.
复制标题
使用微流控装置产生基于PEGDA的光聚合微粒。部分1.材料的初始蠕变时间和机械性能。
DOI：
10.3390/mi12030293
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发表时间：
2021-03-10
期刊：
影响因子：
3.4
通讯作者：
González-Reynoso O
中科院分区：
文献类型：
--
作者：
Acosta-Cuevas JM;González-García J;García-Ramírez M;Pérez-Luna VH;Cisneros-López EO;González-Nuñez R;González-Reynoso O
光聚合微粒由生物相容性水凝胶如聚乙二醇二丙烯酸酯（PEGDA）通过使用微流体装置制成，是用于包封、运输和保留生物或毒性剂的良好选择。由于这些微粒的不同应用，重要的是要研究其组成材料的配方和机械性能。因此，在本研究中，进行了机械试验，以确定不同水凝胶制剂的溶胀、干燥、可溶性分数、压缩、交联密度（）和网孔尺寸（）特性。测试提供了足够的数据来选择最佳配方，用于使用微流体装置的未来一代微粒。水凝胶制剂的初始胶凝时间被估计用于它们在微流体装置内的光聚合过程中的用途。结果表明，PEGDA的用量与凝胶的力学性能和初始凝胶化时间密切相关。因此，了解本研究中制备的水凝胶的机械性能对于它们的正确操作和应用是相当重要的。另一方面，初始胶凝时间在光聚合水凝胶及其在连续系统如微流体装置中的使用中是至关重要的。
Photopolymerized microparticles are made of biocompatible hydrogels like Polyethylene Glycol Diacrylate (PEGDA) by using microfluidic devices are a good option for encapsulation, transport and retention of biological or toxic agents. Due to the different applications of these microparticles, it is important to investigate the formulation and the mechanical properties of the material of which they are made of. Therefore, in the present study, mechanical tests were carried out to determine the swelling, drying, soluble fraction, compression, cross-linking density () and mesh size () properties of different hydrogel formulations. Tests provided sufficient data to select the best formulation for the future generation of microparticles using microfluidic devices. The initial gelation times of the hydrogels formulations were estimated for their use in the photopolymerization process inside a microfluidic device. Obtained results showed a close relationship between the amount of PEGDA used in the hydrogel and its mechanical properties as well as its initial gelation time. Consequently, it is of considerable importance to know the mechanical properties of the hydrogels made in this research for their proper manipulation and application. On the other hand, the initial gelation time is crucial in photopolymerizable hydrogels and their use in continuous systems such as microfluidic devices.
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影响因子：
6.2
作者：
Park, Hansoo;Guo, Xuan;Temenoff, Johnna S.;Tabata, Yasuhiko;Caplan, Arnold I.;Kasper, F. Kurtis;Mikos, Antonios G.
通讯作者：
Mikos, Antonios G.
影响因子：
24.2
作者：
Ionov, Leonid
通讯作者：
Ionov, Leonid
DOI：
10.1002/advs.201600190
发表时间：
2017-02
期刊：
Advanced science (Weinheim, Baden-Wurttemberg, Germany)
影响因子：
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影响因子：
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作者：
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通讯作者：
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DOI：
10.3791/1590
发表时间：
2009-10-26
期刊：
Journal of visualized experiments : JoVE
影响因子：
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作者：
Khetan, Sudhir;Burdick, Jason
通讯作者：
Burdick, Jason