Hepatic Oleate Regulates Insulin-like Growth Factor-Binding Protein 1 Partially through the mTORC1-FGF21 Axis during High-Carbohydrate Feeding.
Hepatic Oleate Regulates Insulin-like Growth Factor-Binding Protein 1 Partially through the mTORC1-FGF21 Axis during High-Carbohydrate Feeding.
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DOI：
10.3390/ijms232314671
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发表时间：
2022-11-24
影响因子：
5.6
通讯作者：
中科院分区：
文献类型：
--
作者：
硬脂酰辅酶A脱饱和酶-1(SCD1)催化单不饱和脂肪酸生物合成的限速步骤，是系统糖代谢的关键调节因子。携带SCD1全局(GKO)或肝脏特异性缺失(LKO)的小鼠表现出增强的胰岛素信号和全身葡萄糖摄取。此外，GKO和LKO小鼠可以免受高碳水化合物饮食诱导的肥胖。鉴于高碳水化合物饮食可导致慢性代谢性疾病，如肥胖、糖尿病和肝脏脂肪变性，了解SCD1缺乏如何赋予代谢有益的表型至关重要。在这里，我们发现胰岛素样生长因子结合蛋白1(IGFBP1)，一种已被报道增强胰岛素信号转导的肝细胞因子，在喂食低脂肪高碳水化合物饮食的GKO和LKO小鼠的肝脏和血浆中显著升高。我们还观察到，在体内和体外，肝脏Igfbp1的表达都受到SCD1的产物油酸(18：1n9)通过mTORC1-FGF21轴的调节。
Stearoyl-CoA desaturase-1 (SCD1) catalyzes the rate-liming step of monounsaturated fatty acid biosynthesis and is a key regulator of systemic glucose metabolism. Mice harboring either a global (GKO) or liver-specific deletion (LKO) of Scd1 display enhanced insulin signaling and whole-body glucose uptake. Additionally, GKO and LKO mice are protected from high-carbohydrate diet-induced obesity. Given that high-carbohydrate diets can lead to chronic metabolic diseases such as obesity, diabetes, and hepatic steatosis, it is critical to understand how Scd1 deficiency confers metabolically beneficial phenotypes. Here we show that insulin-like growth factor-binding protein 1 (IGFBP1), a hepatokine that has been reported to enhance insulin signaling, is significantly elevated in the liver and plasma of GKO and LKO mice fed a low-fat high-carbohydrate diet. We also observed that the expression of hepatic Igfbp1 is regulated by oleic acid (18:1n9), a product of SCD1, through the mTORC1-FGF21 axis both in vivo and in vitro.
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影响因子：
64.5
作者：
Cao H;Gerhold K;Mayers JR;Wiest MM;Watkins SM;Hotamisligil GS
通讯作者：
Hotamisligil GS
影响因子：
8.2
作者：
Heald, AH;Cruickshank, JK;Gibson, JM
通讯作者：
Gibson, JM
影响因子：
5.8
作者：
Liew, CF;Wise, SD;Lee, KO
通讯作者：
Lee, KO
循环的FGF21是肝脏的，并在进食和过度喂养过程中增强了葡萄糖的摄取。
影响因子：
7.7
作者：
Markan KR;Naber MC;Ameka MK;Anderegg MD;Mangelsdorf DJ;Kliewer SA;Mohammadi M;Potthoff MJ
通讯作者：
Potthoff MJ
DOI：
10.1073/pnas.132384699
发表时间：
2002-08-20
影响因子：
11.1
作者：
Ntambi, JM;Miyazaki, M;Attie, AD
通讯作者：
Attie, AD