Thalamic volume deficit contributes to procedural and explicit memory impairment in HIV infection with primary alcoholism comorbidity.
Thalamic volume deficit contributes to procedural and explicit memory impairment in HIV infection with primary alcoholism comorbidity.
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DOI：
10.1007/s11682-013-9286-4
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发表时间：
2014-12
影响因子：
3.2
通讯作者：
Sullivan, Edith V.
中科院分区：
文献类型：
--
作者：
Fama, Rosemary;Rosenbloom, Margaret J.;Sassoon, Stephanie A.;Rohlfing, Torsten;Pfefferbaum, Adolf;Sullivan, Edith V.
关键词：
在HIV感染合并慢性酒精中毒（HIV+ALC）患者中，导致视觉程序性学习减少的认知和运动过程包括注意力和外显记忆过程的问题。与HIV感染和酒精中毒中认知和运动过程相关的神经相关性尚未被描述。额纹状体区域在HIV感染中受到影响，额丘脑小脑区域在慢性酒精中毒中受到影响，额边缘区域可能在两者中受到影响;所有这三个系统都有可能有助于视觉程序学习和外显记忆过程。在这里，我们研究了26例HIV+ALC（5例合并非酒精药物滥用/依赖）和19例年龄范围匹配的健康对照男性的内隐记忆，外显记忆，注意力和运动测试的神经相关性。使用SRI 24脑图谱推导出了包裹的脑体积，包括皮质、皮质下和异皮质区域，以及皮质沟和脑室。结果表明，在HIV+ALC中，较小的丘脑体积与外显（即时和延迟）和内隐（视觉程序）记忆测试的较差表现相关。相比之下，较小的海马体体积与外显记忆分数较低有关，但与内隐记忆无关。多元回归分析显示，丘脑和海马体的体积都是外显记忆分数的独立预测因子。这项研究提供了证据，内隐和外显记忆任务之间的分离，在HIV+ALC，海马体积和外显记忆，但不是内隐记忆之间观察到的选择性关系，并强调了相关的丘脑记忆过程。
Component cognitive and motor processes contributing to diminished visuomotor procedural learning in HIV infection with comorbid chronic alcoholism (HIV+ALC) include problems with attention and explicit memory processes. The neural correlates associated with this constellation of cognitive and motor processes in HIV infection and alcoholism have yet to be delineated. Frontostriatal regions are affected in HIV infection, frontothalamocerebellar regions are affected in chronic alcoholism, and frontolimbic regions are likely affected in both; all three of these systems have the potential of contributing to both visuomotor procedural learning and explicit memory processes. Here, we examined the neural correlates of implicit memory, explicit memory, attention, and motor tests in 26 HIV+ALC (5 with comorbidity for nonalcohol drug abuse/dependence) and 19 age-range matched healthy control men. Parcellated brain volumes, including cortical, subcortical, and allocortical regions, as well as cortical sulci and ventricles, were derived using the SRI24 brain atlas. Results indicated that smaller thalamic volumes were associated with poorer performance on tests of explicit (immediate and delayed) and implicit (visuomotor procedural) memory in HIV+ALC. By contrast, smaller hippocampal volumes were associated with lower scores on explicit, but not implicit memory. Multiple regression analyses revealed that volumes of both the thalamus and the hippocampus were each unique independent predictors of explicit memory scores. This study provides evidence of a dissociation between implicit and explicit memory tasks in HIV+ALC, with selective relationships observed between hippocampal volume and explicit but not implicit memory, and highlights the relevance of the thalamus to mnemonic processes.
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影响因子：
3.2
作者：
Heaton, Robert K.;Franklin, Donald R.;Ellis, Ronald J.;McCutchan, J. Allen;Letendre, Scott L.;LeBlanc, Shannon;Corkran, Stephanie H.;Duarte, Nichole A.;Clifford, David B.;Woods, Steven P.;Collier, Ann C.;Marra, Christina M.;Morgello, Susan;Mindt, Monica Rivera;Taylor, Michael J.;Marcotte, Thomas D.;Atkinson, J. Hampton;Wolfson, Tanya;Gelman, Benjamin B.;McArthur, Justin C.;Simpson, David M.;Abramson, Ian;Gamst, Anthony;Fennema-Notestine, Christine;Jernigan, Terry L.;Wong, Joseph;Grant, Igor
通讯作者：
Grant, Igor
影响因子：
--
作者：
Buxton, CE;Grant, DA
通讯作者：
Grant, DA
DOI：
10.1111/j.2517-6161.1995.tb02031.x
发表时间：
1995-01-01
影响因子：
5.8
作者：
BENJAMINI, Y;HOCHBERG, Y
通讯作者：
HOCHBERG, Y
影响因子：
2.6
作者：
CORKIN, S
通讯作者：
CORKIN, S
影响因子：
9.9
作者：
Chang, L;Speck, O;Ernst, T
通讯作者：
Ernst, T