Is Coffee Consumption associated with Age-related Macular Degeneration and Diabetic Retinopathy?
Is Coffee Consumption associated with Age-related Macular Degeneration and Diabetic Retinopathy?
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咖啡消费与年龄相关性黄斑变性和糖尿病视网膜病变有关吗？
DOI：
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
Neelam Kumari
中科院分区：
文献类型：
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作者：
Neelam Kumari
简介 咖啡是世界上消费最广泛的饮料之一。几项流行病学研究评估了咖啡摄入量与全身性疾病风险之间的关联；然而，有关咖啡消费和眼病风险的数据却很少。本研究旨在探讨新加坡多民族人群中咖啡摄入量与年龄相关性黄斑变性（AMD）和糖尿病性视网膜病变（DR）风险之间的关系。材料和方法 我们分析了来自新加坡前瞻性研究计划的 4121 名研究参与者的数据，以研究咖啡与 AMD 和 DR 患病率的关系。所有研究参与者都完成了一份标准化调查问卷，其中包括有关习惯饮用咖啡量的信息。使用动脉粥样硬化分级协议的 Mutiethnic 研究，通过眼底照片评估 AMD 和 DR 的存在和严重程度。结果我国人群AMD和DR的患病率分别为5.4%和32.0%。 77.5% 的 AMD 人群和 76.1% 的 DR 人群有咖啡消费史，大多数参与者每天喝 1-2 杯咖啡。调整混杂因素后，咖啡摄入量与 AMD 或 DR 的几率之间没有观察到统计学上的显着关联 [AMD：比值比 (OR) = 1.27，置信区间 (CI) = 0.88-1.83，p = 0.20； DR：OR = 1.36，CI = 0.69-2.69，p = 0.37）。结论 这项针对大量多种族人口数据集的流行病学研究并不支持亚洲人习惯性摄入咖啡和咖啡因与 AMD 和 DR 风险改变相关的假设。
Introduction Coffee is among the most widely consumed beverages in the world. Several epidemiological studies have evaluated the association between coffee consumption and risk of systemic diseases; however, there is paucity of data in relation to coffee consumption and risk of eye diseases. This study aims to examine the relationship between coffee consumption and risk of age-related macular degeneration (AMD) and diabetic retinopathy (DR) in multiethnic population of Singapore. Materials and Methods We analyzed the data from 4121 study participants from the Singapore Prospective Study Program to examine the relationship of coffee to prevalence of AMD and DR. A standardized questionnaire that included information about the habitual amount of coffee consumed was completed by all study participants. Presence and severity of AMD and DR was assessed on fundus photographs using the Mutiethnic Study of Atherosclerosis Grading Protocol. Results The prevalence of AMD and DR in our population was 5.4% and 32.0%, respectively. A positive history of coffee consumption was present in 77.5% of AMD population and 76.1% of DR population with majority of participants consuming 1-2 cups of coffee daily. No statistically significant association was observed between coffee consumption and odds of AMD or DR after adjusting for confounding factors [AMD: Odds Ratio (OR) = 1.27, Confidence Interval (CI) = 0.88-1.83, p = 0.20; DR: OR = 1.36, CI = 0.69-2.69, p = 0.37). Conclusion This epidemiological study of a large multiethnic population data set do not support the hypothesis that habitual intake of coffee and caffeine is associated with an altered risk of AMD and DR among Asians.
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DOI：
10.1093/ajcn/88.4.979
发表时间：
2008-10
期刊：
The American journal of clinical nutrition
影响因子：
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作者：
Odegaard AO;Pereira MA;Koh WP;Arakawa K;Lee HP;Yu MC
通讯作者：
Yu MC
影响因子：
4.2
作者：
Svilaas, A;Sakhi, AK;Blomhoff, R
通讯作者：
Blomhoff, R
使用检眼镜、免散瞳相机和标准眼底相机检测到的糖尿病视网膜病变。
影响因子：
13.7
作者：
Klein,R;Klein,BE;Neider,MW;Hubbard,LD;Meuer,SM;Brothers,RJ
通讯作者：
Brothers,RJ
影响因子：
4.4
作者：
Wong, Tien Yin;Islam, F. M. Amirul;Shahar, Eyal
通讯作者：
Shahar, Eyal