Successful treatment with risperidone increases 5-HT 3A receptor gene expression in patients with paranoid schizophrenia - data from a prospective study.
Successful treatment with risperidone increases 5-HT 3A receptor gene expression in patients with paranoid schizophrenia - data from a prospective study.
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DOI：
10.1002/brb3.798
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发表时间：
2017-09
影响因子：
3.1
通讯作者：
Li Z
中科院分区：
文献类型：
--
作者：
Chen H;Fan Y;Zhao L;Hao Y;Zhou X;Guan Y;Li Z
偏执型精神分裂症患者外周血5-HT3A受体mRNA水平与利培酮疗效的关系尚不清楚。52例首发未服药的偏执型精神分裂症患者接受利培酮治疗，53例健康对照组入选。对患者进行8周的自然随访。用阳性和阴性症状量表(PANSS)评定患者基线和第8周末的症状严重程度。偏执型精神分裂症患者5-HT3A受体基因表达水平与正常对照组比较差异无统计学意义(P>0.05)。在完成8周自然随访的47名患者中，37名患者对利培酮治疗有反应。利培酮治疗8周后，偏执型精神分裂症患者5-HT3A受体基因表达水平无明显变化(p=2.29)。然而，应答者的5-HT3A受体mRNA水平显著增加(p=5.04)，而无应答者的5-HT3A受体mRNA水平则没有增加(p=2.81)。利培酮治疗成功可增加偏执型精神分裂症患者5-HT3A受体基因的表达，提示5-HT3A受体可能参与了利培酮的作用机制。
The relationship between peripheral 5‐HT3A receptor mRNA level and risperidone efficiency in paranoid schizophrenia patients is still unknown. A total 52 first‐episode and drug‐naive paranoid schizophrenia patients who were treated with risperidone and 53 matched healthy controls were enrolled. Patients were naturalistically followed up for 8 weeks. Positive and Negative Syndrome Scale (PANSS) was applied to assess symptom severity of the patients at baseline and at the end of 8th week. There was no difference in 5‐HT3A receptor mRNA level between paranoid schizophrenia patients and healthy controls at baseline (p = .24). Among 47 patients who completed 8‐week naturalistic follow‐up, 37 were responders to risperidone treatment. 5‐HT3A receptor mRNA level of paranoid schizophrenia patients did not change in overall patients after 8‐week treatment with risperidone (p = .29). However, 5‐HT3A receptor mRNA level in responders increased significantly (p = .04), but not in nonresponders (p = .81). Successful treatment with risperidone increases 5‐HT3A receptor gene expression in patients with paranoid schizophrenia, indicating that 5‐HT3A receptor may be involved in the mechanism of risperidone effect.
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影响因子：
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作者：
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DOI：
10.1073/pnas.40.4.228
发表时间：
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影响因子：
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作者：
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通讯作者：
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